Divergent Picobirnaviruses in Human Feces

The near-complete genomes of two picobirnaviruses (PBVs) in diarrheal stool samples, human picobirnaviruses D and E (HuPBV-D and -E), were genetically characterized. Their RNA-dependent RNA polymerase (RdRp) protein sequences had <66% identities to known PBVs. Due to a single nucleotide insertion...

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Detalles Bibliográficos
Autores principales: Ng, Terry Fei Fan, Vega, Everardo, Kondov, Nikola O., Markey, Christopher, Deng, Xutao, Gregoricus, Nicole, Vinjé, Jan, Delwart, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Viruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022810/
https://www.ncbi.nlm.nih.gov/pubmed/24831146
http://dx.doi.org/10.1128/genomeA.00415-14
Descripción
Sumario:The near-complete genomes of two picobirnaviruses (PBVs) in diarrheal stool samples, human picobirnaviruses D and E (HuPBV-D and -E), were genetically characterized. Their RNA-dependent RNA polymerase (RdRp) protein sequences had <66% identities to known PBVs. Due to a single nucleotide insertion, the open reading frame 2 (ORF2) in segment 1 of HuPBV-D was interrupted by a stop codon. A small stem-loop structure overlying the stop codon may result in translational readthrough into the rest of ORF2.

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