Divergent Picobirnaviruses in Human Feces

The near-complete genomes of two picobirnaviruses (PBVs) in diarrheal stool samples, human picobirnaviruses D and E (HuPBV-D and -E), were genetically characterized. Their RNA-dependent RNA polymerase (RdRp) protein sequences had <66% identities to known PBVs. Due to a single nucleotide insertion...

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Autores principales: Ng, Terry Fei Fan, Vega, Everardo, Kondov, Nikola O., Markey, Christopher, Deng, Xutao, Gregoricus, Nicole, Vinjé, Jan, Delwart, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Viruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022810/
https://www.ncbi.nlm.nih.gov/pubmed/24831146
http://dx.doi.org/10.1128/genomeA.00415-14
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author Ng, Terry Fei Fan
Vega, Everardo
Kondov, Nikola O.
Markey, Christopher
Deng, Xutao
Gregoricus, Nicole
Vinjé, Jan
Delwart, Eric
author_facet Ng, Terry Fei Fan
Vega, Everardo
Kondov, Nikola O.
Markey, Christopher
Deng, Xutao
Gregoricus, Nicole
Vinjé, Jan
Delwart, Eric
author_sort Ng, Terry Fei Fan
collection PubMed
description The near-complete genomes of two picobirnaviruses (PBVs) in diarrheal stool samples, human picobirnaviruses D and E (HuPBV-D and -E), were genetically characterized. Their RNA-dependent RNA polymerase (RdRp) protein sequences had <66% identities to known PBVs. Due to a single nucleotide insertion, the open reading frame 2 (ORF2) in segment 1 of HuPBV-D was interrupted by a stop codon. A small stem-loop structure overlying the stop codon may result in translational readthrough into the rest of ORF2.
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spelling pubmed-40228102014-05-16 Divergent Picobirnaviruses in Human Feces Ng, Terry Fei Fan Vega, Everardo Kondov, Nikola O. Markey, Christopher Deng, Xutao Gregoricus, Nicole Vinjé, Jan Delwart, Eric Genome Announc Viruses The near-complete genomes of two picobirnaviruses (PBVs) in diarrheal stool samples, human picobirnaviruses D and E (HuPBV-D and -E), were genetically characterized. Their RNA-dependent RNA polymerase (RdRp) protein sequences had <66% identities to known PBVs. Due to a single nucleotide insertion, the open reading frame 2 (ORF2) in segment 1 of HuPBV-D was interrupted by a stop codon. A small stem-loop structure overlying the stop codon may result in translational readthrough into the rest of ORF2. American Society for Microbiology 2014-05-15 /pmc/articles/PMC4022810/ /pubmed/24831146 http://dx.doi.org/10.1128/genomeA.00415-14 Text en Copyright © 2014 Ng et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Viruses
Ng, Terry Fei Fan
Vega, Everardo
Kondov, Nikola O.
Markey, Christopher
Deng, Xutao
Gregoricus, Nicole
Vinjé, Jan
Delwart, Eric
Divergent Picobirnaviruses in Human Feces
title Divergent Picobirnaviruses in Human Feces
title_full Divergent Picobirnaviruses in Human Feces
title_fullStr Divergent Picobirnaviruses in Human Feces
title_full_unstemmed Divergent Picobirnaviruses in Human Feces
title_short Divergent Picobirnaviruses in Human Feces
title_sort divergent picobirnaviruses in human feces
topic Viruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022810/
https://www.ncbi.nlm.nih.gov/pubmed/24831146
http://dx.doi.org/10.1128/genomeA.00415-14
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