Interactions Outside the Proteinase-binding Loop Contribute Significantly to the Inhibition of Activated Coagulation Factor XII by Its Canonical Inhibitor from Corn

Activated factor XII (FXIIa) is selectively inhibited by corn Hageman factor inhibitor (CHFI) among other plasma proteases. CHFI is considered a canonical serine protease inhibitor that interacts with FXIIa through its protease-binding loop. Here we examined whether the protease-binding loop alone i...

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Detalles Bibliográficos
Autores principales: Korneeva, Vera A., Trubetskov, Mikhail M., Korshunova, Alena V., Lushchekina, Sofya V., Kolyadko, Vladimir N., Sergienko, Olga V., Lunin, Vladimir G., Panteleev, Mikhail A., Ataullakhanov, Fazoil I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022879/
https://www.ncbi.nlm.nih.gov/pubmed/24706752
http://dx.doi.org/10.1074/jbc.M114.553735

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