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Aging interferes central control mechanism for eccentric muscle contraction

Previous studies report greater activation in the cortical motor network in controlling eccentric contraction (EC) than concentric contraction (CC) despite lower muscle activation level associated with EC vs. CC in healthy, young individuals. It is unknown, however, whether elderly people exhibiting...

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Autores principales: Yao, Wan X., Li, Jinqi, Jiang, Zhiguo, Gao, Jia-Hong, Franklin, Crystal G., Huang, Yufei, Lancaster, Jack L., Yue, Guang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023019/
https://www.ncbi.nlm.nih.gov/pubmed/24847261
http://dx.doi.org/10.3389/fnagi.2014.00086
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author Yao, Wan X.
Li, Jinqi
Jiang, Zhiguo
Gao, Jia-Hong
Franklin, Crystal G.
Huang, Yufei
Lancaster, Jack L.
Yue, Guang H.
author_facet Yao, Wan X.
Li, Jinqi
Jiang, Zhiguo
Gao, Jia-Hong
Franklin, Crystal G.
Huang, Yufei
Lancaster, Jack L.
Yue, Guang H.
author_sort Yao, Wan X.
collection PubMed
description Previous studies report greater activation in the cortical motor network in controlling eccentric contraction (EC) than concentric contraction (CC) despite lower muscle activation level associated with EC vs. CC in healthy, young individuals. It is unknown, however, whether elderly people exhibiting increased difficulties in performing EC than CC possess this unique cortical control mechanism for EC movements. To address this question, we examined functional magnetic resonance imaging (fMRI) data acquired during EC and CC of the first dorsal interosseous (FDI) muscle in 11 young (20–32 years) and 9 old (67–73 years) individuals. During the fMRI experiment, all subjects performed 20 CC and 20 EC of the right FDI with the same angular distance and velocity. The major findings from the behavioral and fMRI data analysis were that (1) movement stability was poorer in EC than CC in the old but not the young group; (2) similar to previous electrophysiological and fMRI reports, the EC resulted in significantly stronger activation in the motor control network consisting of primary, secondary and association motor cortices than CC in the young and old groups; (3) the biased stronger activation towards EC was significantly greater in the old than the young group especially in the secondary and association cortices such as supplementary and premotor motor areas and anterior cingulate cortex; and (4) in the primary motor and sensory cortices, the biased activation towards EC was significantly greater in the young than the old group. Greater activation in higher-order cortical fields for controlling EC movement by elderly adults may reflect activities in these regions to compensate for aging-related impairments in the ability to control complex EC movements. Our finding is useful for potentially guiding the development of targeted therapies to counteract age-related movement deficits and to prevent injury.
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spelling pubmed-40230192014-05-20 Aging interferes central control mechanism for eccentric muscle contraction Yao, Wan X. Li, Jinqi Jiang, Zhiguo Gao, Jia-Hong Franklin, Crystal G. Huang, Yufei Lancaster, Jack L. Yue, Guang H. Front Aging Neurosci Neuroscience Previous studies report greater activation in the cortical motor network in controlling eccentric contraction (EC) than concentric contraction (CC) despite lower muscle activation level associated with EC vs. CC in healthy, young individuals. It is unknown, however, whether elderly people exhibiting increased difficulties in performing EC than CC possess this unique cortical control mechanism for EC movements. To address this question, we examined functional magnetic resonance imaging (fMRI) data acquired during EC and CC of the first dorsal interosseous (FDI) muscle in 11 young (20–32 years) and 9 old (67–73 years) individuals. During the fMRI experiment, all subjects performed 20 CC and 20 EC of the right FDI with the same angular distance and velocity. The major findings from the behavioral and fMRI data analysis were that (1) movement stability was poorer in EC than CC in the old but not the young group; (2) similar to previous electrophysiological and fMRI reports, the EC resulted in significantly stronger activation in the motor control network consisting of primary, secondary and association motor cortices than CC in the young and old groups; (3) the biased stronger activation towards EC was significantly greater in the old than the young group especially in the secondary and association cortices such as supplementary and premotor motor areas and anterior cingulate cortex; and (4) in the primary motor and sensory cortices, the biased activation towards EC was significantly greater in the young than the old group. Greater activation in higher-order cortical fields for controlling EC movement by elderly adults may reflect activities in these regions to compensate for aging-related impairments in the ability to control complex EC movements. Our finding is useful for potentially guiding the development of targeted therapies to counteract age-related movement deficits and to prevent injury. Frontiers Media S.A. 2014-05-09 /pmc/articles/PMC4023019/ /pubmed/24847261 http://dx.doi.org/10.3389/fnagi.2014.00086 Text en Copyright © 2014 Yao, Li, Jiang, Gao, Franklin, Huang, Lancaster and Yue. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yao, Wan X.
Li, Jinqi
Jiang, Zhiguo
Gao, Jia-Hong
Franklin, Crystal G.
Huang, Yufei
Lancaster, Jack L.
Yue, Guang H.
Aging interferes central control mechanism for eccentric muscle contraction
title Aging interferes central control mechanism for eccentric muscle contraction
title_full Aging interferes central control mechanism for eccentric muscle contraction
title_fullStr Aging interferes central control mechanism for eccentric muscle contraction
title_full_unstemmed Aging interferes central control mechanism for eccentric muscle contraction
title_short Aging interferes central control mechanism for eccentric muscle contraction
title_sort aging interferes central control mechanism for eccentric muscle contraction
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023019/
https://www.ncbi.nlm.nih.gov/pubmed/24847261
http://dx.doi.org/10.3389/fnagi.2014.00086
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