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Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors
To determine visual outcome including the occurrence of radiation induced optic neuropathy (RION) as well as tumor control after fractionated stereotactic radiation therapy (FSRT) of benign anterior skull base meningiomas or pituitary adenomas. Thirty-nine patients treated with FSRT for anterior sku...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023078/ https://www.ncbi.nlm.nih.gov/pubmed/24532196 http://dx.doi.org/10.1007/s11060-014-1399-0 |
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author | Astradsson, Arnar Wiencke, Anne Katrine Munck af Rosenschold, Per Engelholm, Svend-Aage Ohlhues, Lars Roed, Henrik Juhler, Marianne |
author_facet | Astradsson, Arnar Wiencke, Anne Katrine Munck af Rosenschold, Per Engelholm, Svend-Aage Ohlhues, Lars Roed, Henrik Juhler, Marianne |
author_sort | Astradsson, Arnar |
collection | PubMed |
description | To determine visual outcome including the occurrence of radiation induced optic neuropathy (RION) as well as tumor control after fractionated stereotactic radiation therapy (FSRT) of benign anterior skull base meningiomas or pituitary adenomas. Thirty-nine patients treated with FSRT for anterior skull base meningiomas and 55 patients treated with FSRT for pituitary adenomas between January 1999 and December 2009 with at least 2 years follow-up were included. Patients were followed up prospectively with magnetic resonance imaging scans, visual acuity and visual field examinations. RION was found in four (10 %) patients with anterior skull base meningiomas and seven patients (13 %) with pituitary adenomas. The five-year actuarial freedom from 25 % RION visual field loss was 94 % following FSRT. Actuarial 2-, 5- and 10-year tumor control rates were 100, 88.4 and 64.5 % for anterior skull base meningiomas and 100, 98.2 and 94.9 % for pituitary adenomas, respectively. Patients with an impaired visual field function pre-FSRT were more likely to experience worsened function (p = 0.016). We found that RION, was a relatively uncommon event, in a large prospective cohort of patients that were systematically monitored following FSRT of benign anterior skull base tumors. Long term tumor control was favorable, especially for pituitary adenomas. |
format | Online Article Text |
id | pubmed-4023078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-40230782014-05-16 Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors Astradsson, Arnar Wiencke, Anne Katrine Munck af Rosenschold, Per Engelholm, Svend-Aage Ohlhues, Lars Roed, Henrik Juhler, Marianne J Neurooncol Clinical Study To determine visual outcome including the occurrence of radiation induced optic neuropathy (RION) as well as tumor control after fractionated stereotactic radiation therapy (FSRT) of benign anterior skull base meningiomas or pituitary adenomas. Thirty-nine patients treated with FSRT for anterior skull base meningiomas and 55 patients treated with FSRT for pituitary adenomas between January 1999 and December 2009 with at least 2 years follow-up were included. Patients were followed up prospectively with magnetic resonance imaging scans, visual acuity and visual field examinations. RION was found in four (10 %) patients with anterior skull base meningiomas and seven patients (13 %) with pituitary adenomas. The five-year actuarial freedom from 25 % RION visual field loss was 94 % following FSRT. Actuarial 2-, 5- and 10-year tumor control rates were 100, 88.4 and 64.5 % for anterior skull base meningiomas and 100, 98.2 and 94.9 % for pituitary adenomas, respectively. Patients with an impaired visual field function pre-FSRT were more likely to experience worsened function (p = 0.016). We found that RION, was a relatively uncommon event, in a large prospective cohort of patients that were systematically monitored following FSRT of benign anterior skull base tumors. Long term tumor control was favorable, especially for pituitary adenomas. Springer US 2014-02-15 2014 /pmc/articles/PMC4023078/ /pubmed/24532196 http://dx.doi.org/10.1007/s11060-014-1399-0 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Clinical Study Astradsson, Arnar Wiencke, Anne Katrine Munck af Rosenschold, Per Engelholm, Svend-Aage Ohlhues, Lars Roed, Henrik Juhler, Marianne Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors |
title | Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors |
title_full | Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors |
title_fullStr | Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors |
title_full_unstemmed | Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors |
title_short | Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors |
title_sort | visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023078/ https://www.ncbi.nlm.nih.gov/pubmed/24532196 http://dx.doi.org/10.1007/s11060-014-1399-0 |
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