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Epistatic Interactions between CREB and CREM Variants in Affective Disorder

The aim of the present work is to investigate the existence of epistatic interactions possibly influencing psychotropic agents' response between rs6740584 within Cyclic adenosine monophosphate Response Element Binding (CREB) and rs12775799 within cAMP response element-modulator (CREM) variants...

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Autores principales: Chiesa, Alberto, Marsano, Agnese, Han, Changsu, Lee, Soo-Jung, Patkar, Ashwin A., Pae, Chi-Un, Serretti, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023096/
https://www.ncbi.nlm.nih.gov/pubmed/24843377
http://dx.doi.org/10.4306/pi.2014.11.2.200
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author Chiesa, Alberto
Marsano, Agnese
Han, Changsu
Lee, Soo-Jung
Patkar, Ashwin A.
Pae, Chi-Un
Serretti, Alessandro
author_facet Chiesa, Alberto
Marsano, Agnese
Han, Changsu
Lee, Soo-Jung
Patkar, Ashwin A.
Pae, Chi-Un
Serretti, Alessandro
author_sort Chiesa, Alberto
collection PubMed
description The aim of the present work is to investigate the existence of epistatic interactions possibly influencing psychotropic agents' response between rs6740584 within Cyclic adenosine monophosphate Response Element Binding (CREB) and rs12775799 within cAMP response element-modulator (CREM) variants in bipolar disorder (BD) and major depressive disorder (MDD). All BD and MDD patients were administered with the Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HAMD) at baseline and at endpoint, respectively. A multiple regression model was employed to investigate the existence of possible epistatic interactions between the two variants and diverse clinical factors including drug response in affective disorders. No significant epistatic interaction was observed between rs6740584 within CREB and rs12775799 within CREM on both symptom improvement and other clinical factors in affective disorders. Our preliminary results suggest that no epistatic interaction between rs6740584 within CREB and rs12775799 within CREM should exist on clinical improvement and clinical factors in affective disorders.
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spelling pubmed-40230962014-05-19 Epistatic Interactions between CREB and CREM Variants in Affective Disorder Chiesa, Alberto Marsano, Agnese Han, Changsu Lee, Soo-Jung Patkar, Ashwin A. Pae, Chi-Un Serretti, Alessandro Psychiatry Investig Brief Report The aim of the present work is to investigate the existence of epistatic interactions possibly influencing psychotropic agents' response between rs6740584 within Cyclic adenosine monophosphate Response Element Binding (CREB) and rs12775799 within cAMP response element-modulator (CREM) variants in bipolar disorder (BD) and major depressive disorder (MDD). All BD and MDD patients were administered with the Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HAMD) at baseline and at endpoint, respectively. A multiple regression model was employed to investigate the existence of possible epistatic interactions between the two variants and diverse clinical factors including drug response in affective disorders. No significant epistatic interaction was observed between rs6740584 within CREB and rs12775799 within CREM on both symptom improvement and other clinical factors in affective disorders. Our preliminary results suggest that no epistatic interaction between rs6740584 within CREB and rs12775799 within CREM should exist on clinical improvement and clinical factors in affective disorders. Korean Neuropsychiatric Association 2014-04 2014-04-11 /pmc/articles/PMC4023096/ /pubmed/24843377 http://dx.doi.org/10.4306/pi.2014.11.2.200 Text en Copyright © 2014 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Chiesa, Alberto
Marsano, Agnese
Han, Changsu
Lee, Soo-Jung
Patkar, Ashwin A.
Pae, Chi-Un
Serretti, Alessandro
Epistatic Interactions between CREB and CREM Variants in Affective Disorder
title Epistatic Interactions between CREB and CREM Variants in Affective Disorder
title_full Epistatic Interactions between CREB and CREM Variants in Affective Disorder
title_fullStr Epistatic Interactions between CREB and CREM Variants in Affective Disorder
title_full_unstemmed Epistatic Interactions between CREB and CREM Variants in Affective Disorder
title_short Epistatic Interactions between CREB and CREM Variants in Affective Disorder
title_sort epistatic interactions between creb and crem variants in affective disorder
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023096/
https://www.ncbi.nlm.nih.gov/pubmed/24843377
http://dx.doi.org/10.4306/pi.2014.11.2.200
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