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The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

BACKGROUND: Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation in genes in this pathway (IL4, IL4R, IL13, GATA3, and STAT6) influence asthma risk...

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Detalles Bibliográficos
Autores principales:	Zhang, Hongmei, Tong, Xin, Holloway, John W, Rezwan, Faisal I, Lockett, Gabrielle A, Patil, Veeresh, Ray, Meredith, Everson, Todd M, Soto-Ramírez, Nelís, Arshad, S Hasan, Ewart, Susan, Karmaus, Wilfried
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023182/ https://www.ncbi.nlm.nih.gov/pubmed/24735657 http://dx.doi.org/10.1186/1868-7083-6-8

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