Synthesis and Evaluation of Flavanones as Anticancer Agents

A few flavanones were synthesised by cyclisation of corresponding 3-(heteroaryl)-1(2-hydroxyphenyl) prop-2-en-1-one with sodium acetate in alcohol–water and evaluated for activity. Synthesised compounds were assayed for their in vitro anticancer activity against three human cancer cell lines, mammar...

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Detalles Bibliográficos
Autores principales: Murti, Y., Mishra, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023286/
https://www.ncbi.nlm.nih.gov/pubmed/24843190
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author Murti, Y.
Mishra, P.
author_facet Murti, Y.
Mishra, P.
author_sort Murti, Y.
collection PubMed
description A few flavanones were synthesised by cyclisation of corresponding 3-(heteroaryl)-1(2-hydroxyphenyl) prop-2-en-1-one with sodium acetate in alcohol–water and evaluated for activity. Synthesised compounds were assayed for their in vitro anticancer activity against three human cancer cell lines, mammary adenocarcinoma (MCF7), human colon adenocarcinoma (HT29) and human kidney adenocarcinoma (A498) using sulforhodamine B dye. Results indicated that most of the compounds exhibited significant in vitro anticancer potential. Among them, compound having furan ring showed most potent activity against all the tested cell lines.
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spelling pubmed-40232862014-05-19 Synthesis and Evaluation of Flavanones as Anticancer Agents Murti, Y. Mishra, P. Indian J Pharm Sci Short Communication A few flavanones were synthesised by cyclisation of corresponding 3-(heteroaryl)-1(2-hydroxyphenyl) prop-2-en-1-one with sodium acetate in alcohol–water and evaluated for activity. Synthesised compounds were assayed for their in vitro anticancer activity against three human cancer cell lines, mammary adenocarcinoma (MCF7), human colon adenocarcinoma (HT29) and human kidney adenocarcinoma (A498) using sulforhodamine B dye. Results indicated that most of the compounds exhibited significant in vitro anticancer potential. Among them, compound having furan ring showed most potent activity against all the tested cell lines. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4023286/ /pubmed/24843190 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Murti, Y.
Mishra, P.
Synthesis and Evaluation of Flavanones as Anticancer Agents
title Synthesis and Evaluation of Flavanones as Anticancer Agents
title_full Synthesis and Evaluation of Flavanones as Anticancer Agents
title_fullStr Synthesis and Evaluation of Flavanones as Anticancer Agents
title_full_unstemmed Synthesis and Evaluation of Flavanones as Anticancer Agents
title_short Synthesis and Evaluation of Flavanones as Anticancer Agents
title_sort synthesis and evaluation of flavanones as anticancer agents
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023286/
https://www.ncbi.nlm.nih.gov/pubmed/24843190
work_keys_str_mv AT murtiy synthesisandevaluationofflavanonesasanticanceragents
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