Glucocorticoids and prostate cancer treatment: friend or foe?

Glucocorticoids have been used in the treatment of prostate cancer to slow disease progression, improve pain control and offset side effects of chemo- and hormonal therapy. However, they may also have the potential to drive prostate cancer growth via mutated androgen receptors or glucocorticoid rece...

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Detalles Bibliográficos
Autores principales: Montgomery, Bruce, Cheng, Heather H, Drechsler, James, Mostaghel, Elahe A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023359/
https://www.ncbi.nlm.nih.gov/pubmed/24625881
http://dx.doi.org/10.4103/1008-682X.125392
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author Montgomery, Bruce
Cheng, Heather H
Drechsler, James
Mostaghel, Elahe A
author_facet Montgomery, Bruce
Cheng, Heather H
Drechsler, James
Mostaghel, Elahe A
author_sort Montgomery, Bruce
collection PubMed
description Glucocorticoids have been used in the treatment of prostate cancer to slow disease progression, improve pain control and offset side effects of chemo- and hormonal therapy. However, they may also have the potential to drive prostate cancer growth via mutated androgen receptors or glucocorticoid receptors (GRs). In this review we examine historical and contemporary use of glucocorticoids in the treatment of prostate cancer, review potential mechanisms by which they may inhibit or drive prostate cancer growth, and describe potential means of defining their contribution to the biology of prostate cancer.
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spelling pubmed-40233592014-05-22 Glucocorticoids and prostate cancer treatment: friend or foe? Montgomery, Bruce Cheng, Heather H Drechsler, James Mostaghel, Elahe A Asian J Androl Invited Review Glucocorticoids have been used in the treatment of prostate cancer to slow disease progression, improve pain control and offset side effects of chemo- and hormonal therapy. However, they may also have the potential to drive prostate cancer growth via mutated androgen receptors or glucocorticoid receptors (GRs). In this review we examine historical and contemporary use of glucocorticoids in the treatment of prostate cancer, review potential mechanisms by which they may inhibit or drive prostate cancer growth, and describe potential means of defining their contribution to the biology of prostate cancer. Medknow Publications & Media Pvt Ltd 2014 2014-03-07 /pmc/articles/PMC4023359/ /pubmed/24625881 http://dx.doi.org/10.4103/1008-682X.125392 Text en Copyright: © Asian Journal of Andrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review
Montgomery, Bruce
Cheng, Heather H
Drechsler, James
Mostaghel, Elahe A
Glucocorticoids and prostate cancer treatment: friend or foe?
title Glucocorticoids and prostate cancer treatment: friend or foe?
title_full Glucocorticoids and prostate cancer treatment: friend or foe?
title_fullStr Glucocorticoids and prostate cancer treatment: friend or foe?
title_full_unstemmed Glucocorticoids and prostate cancer treatment: friend or foe?
title_short Glucocorticoids and prostate cancer treatment: friend or foe?
title_sort glucocorticoids and prostate cancer treatment: friend or foe?
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023359/
https://www.ncbi.nlm.nih.gov/pubmed/24625881
http://dx.doi.org/10.4103/1008-682X.125392
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AT mostaghelelahea glucocorticoidsandprostatecancertreatmentfriendorfoe

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