Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

The extracellular signal‐regulated kinase (ERK) signaling pathway controls cell proliferation and differentiation in metazoans. Two hallmarks of its dynamics are adaptation of ERK phosphorylation, which has been linked to negative feedback, and nucleocytoplasmic shuttling, which allows active ERK to...

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Detalles Bibliográficos
Autores principales: Ahmed, Shoeb, Grant, Kyle G, Edwards, Laura E, Rahman, Anisur, Cirit, Murat, Goshe, Michael B, Haugh, Jason M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023404/
https://www.ncbi.nlm.nih.gov/pubmed/24489118
http://dx.doi.org/10.1002/msb.134708

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