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Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review

OBJECTIVE: Recent evidence has associated immune and inflammatory changes to cognitive performance in many diseases, including schizophrenia. Since this is a new research field where concepts are not yet solid and new questions and hypothesis are still arising, the present study aimed at summarizing...

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Autores principales: Ribeiro-Santos, afael, Lucio Teixeira, Antonio, Salgado, João Vinícius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023457/
https://www.ncbi.nlm.nih.gov/pubmed/24851091
http://dx.doi.org/10.2174/1570159X1203140511160832
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author Ribeiro-Santos, afael
Lucio Teixeira, Antonio
Salgado, João Vinícius
author_facet Ribeiro-Santos, afael
Lucio Teixeira, Antonio
Salgado, João Vinícius
author_sort Ribeiro-Santos, afael
collection PubMed
description OBJECTIVE: Recent evidence has associated immune and inflammatory changes to cognitive performance in many diseases, including schizophrenia. Since this is a new research field where concepts are not yet solid and new questions and hypothesis are still arising, the present study aimed at summarizing the available clinical data associating schizophrenia, cognition and inflammation/immune function. METHODS: A systematic review of the literature was made by searching the following terms in Medline: “schizophrenia or psychosis or psychotic” AND “inflamm* or immun* or cytokine or IL-* or TNF-* or kynureni* or KYNA”, AND “cognit* or attention or memory or executive function”. RESULTS: Seventy five papers were identified using the selected terms, and seven papers were included in the review. Papers excluded focused mainly on basic research or other neuropsychiatric disorders. CONCLUSIONS: Recent findings link inflammatory markers to cognition in schizophrenia, suggesting that inflammation is associated with worst cognitive performance. Microglial activation, monoaminergic imbalance, brain abnormalities and the kynurenine pathway are possible mechanisms underlying cognitive impairment in schizophrenia. Clinical trials with addition of immunomodulatory drugs have shown promising results, opening new windows to tackle cognition in schizophrenia.
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spelling pubmed-40234572014-11-01 Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review Ribeiro-Santos, afael Lucio Teixeira, Antonio Salgado, João Vinícius Curr Neuropharmacol Article OBJECTIVE: Recent evidence has associated immune and inflammatory changes to cognitive performance in many diseases, including schizophrenia. Since this is a new research field where concepts are not yet solid and new questions and hypothesis are still arising, the present study aimed at summarizing the available clinical data associating schizophrenia, cognition and inflammation/immune function. METHODS: A systematic review of the literature was made by searching the following terms in Medline: “schizophrenia or psychosis or psychotic” AND “inflamm* or immun* or cytokine or IL-* or TNF-* or kynureni* or KYNA”, AND “cognit* or attention or memory or executive function”. RESULTS: Seventy five papers were identified using the selected terms, and seven papers were included in the review. Papers excluded focused mainly on basic research or other neuropsychiatric disorders. CONCLUSIONS: Recent findings link inflammatory markers to cognition in schizophrenia, suggesting that inflammation is associated with worst cognitive performance. Microglial activation, monoaminergic imbalance, brain abnormalities and the kynurenine pathway are possible mechanisms underlying cognitive impairment in schizophrenia. Clinical trials with addition of immunomodulatory drugs have shown promising results, opening new windows to tackle cognition in schizophrenia. Bentham Science Publishers 2014-05 2014-05 /pmc/articles/PMC4023457/ /pubmed/24851091 http://dx.doi.org/10.2174/1570159X1203140511160832 Text en ©2014 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Ribeiro-Santos, afael
Lucio Teixeira, Antonio
Salgado, João Vinícius
Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review
title Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review
title_full Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review
title_fullStr Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review
title_full_unstemmed Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review
title_short Evidence for an Immune Role on Cognition in Schizophrenia: A Systematic Review
title_sort evidence for an immune role on cognition in schizophrenia: a systematic review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023457/
https://www.ncbi.nlm.nih.gov/pubmed/24851091
http://dx.doi.org/10.2174/1570159X1203140511160832
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