Cargando…

Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins

The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis (ALS) and the majority of frontotemporal lobar degeneration (FTLD-TDP) referred to collectively as TDP-43 proteinopathies. To further elucidate mechanisms of patholog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kwong, Linda K, Irwin, David J, Walker, Adam K, Xu, Yan, Riddle, Dawn M, Trojanowski, John Q, Lee, Virginia M Y
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023626/ https://www.ncbi.nlm.nih.gov/pubmed/24690345 http://dx.doi.org/10.1186/2051-5960-2-33

Ejemplares similares

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
por: Porta, Sílvia, et al.
Publicado: (2018)

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration
por: Yousef, Ahmed, et al.
Publicado: (2017)

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
por: Keating, Sean S., et al.
Publicado: (2023)

Metals in ALS TDP-43 Pathology
por: Koski, Lassi, et al.
Publicado: (2021)

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies
por: Goossens, Joery, et al.
Publicado: (2015)

TDP-43 Pathology in Alzheimer’s Disease
por: Meneses, Axel, et al.
Publicado: (2021)

Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin
por: Amlie-Wolf, Alexandre, et al.
Publicado: (2015)

TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer’s disease and frontotemporal lobar degeneration
por: Foulds, Penelope, et al.
Publicado: (2008)

The Pathological Phenotypes of Human TDP-43 Transgenic Mouse Models Are Independent of Downregulation of Mouse Tdp-43
por: Xu, Ya-Fei, et al.
Publicado: (2013)

Drosha Inclusions Are New Components of Dipeptide-Repeat Protein Aggregates in FTLD-TDP and ALS C9orf72 Expansion Cases
por: Porta, Sílvia, et al.
Publicado: (2015)

Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43
por: Tan, Rachel H, et al.
Publicado: (2013)

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
por: Oiwa, Kotaro, et al.
Publicado: (2023)

Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis
por: Hur, Seong Kwon, et al.
Publicado: (2022)

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes
por: Neumann, Manuela, et al.
Publicado: (2020)

Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease
por: Gibbons, Garrett S., et al.
Publicado: (2020)

Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice
por: Ding, Xuebing, et al.
Publicado: (2021)

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies
por: Koopman, Mandy, et al.
Publicado: (2023)

Molecular, functional, and pathological aspects of TDP-43 fragmentation
por: Chhangani, Deepak, et al.
Publicado: (2021)

TDP43 pathology in chronic traumatic encephalopathy retinas
por: Phansalkar, Ragini, et al.
Publicado: (2023)

Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration
por: Cervantes González, Alba, et al.
Publicado: (2022)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

Concurrent tau pathologies in frontotemporal lobar degeneration with TDP‐43 pathology
por: Koga, Shunsuke, et al.
Publicado: (2021)

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
por: Prasad, Archana, et al.
Publicado: (2019)

TDP-43 pathology in the retina of patients with frontotemporal lobar degeneration
por: Dijkstra, Anke A., et al.
Publicado: (2023)

Evaluation of blood‐based, extracellular vesicles as biomarkers for aging‐related TDP‐43 pathology
por: Winston, Charisse N., et al.
Publicado: (2022)

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
por: Paolicelli, Rosa C., et al.
Publicado: (2017)

Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases
por: Isaacs, A M, et al.
Publicado: (2008)

Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology
por: Tisdall, M. Dylan, et al.
Publicado: (2021)

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation
por: Lee, Saebom, et al.
Publicado: (2022)

TDP-43 pathology is associated with increased tau burdens and seeding
por: Tomé, Sandra O., et al.
Publicado: (2023)

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration
por: Urwin, Hazel, et al.
Publicado: (2010)

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
por: Pickles, Sarah, et al.
Publicado: (2022)

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies
por: Young, Alexandra L, et al.
Publicado: (2023)

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies
por: Young, Alexandra L, et al.
Publicado: (2023)

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
por: Berning, Britt A., et al.
Publicado: (2019)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology
por: Lee, Yi-Chao, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dhdvqhoi3if72rhacruahnog96