Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation

Adjuvants play an essential role in the induction of acquired immunity upon vaccination with protein antigen. In this issue of EMBO Molecular Medicine, a classical type of adjuvant made of DNA oligonucleotide containing CpG motifs, which has already been used in humans, is shown to boost humoral imm...

Descripción completa

Detalles Bibliográficos
Autor principal: Fillatreau, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Closeups
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023880/
https://www.ncbi.nlm.nih.gov/pubmed/24803394
http://dx.doi.org/10.1002/emmm.201404015
_version_ 1782316583780089856
author Fillatreau, Simon
author_facet Fillatreau, Simon
author_sort Fillatreau, Simon
collection PubMed
description Adjuvants play an essential role in the induction of acquired immunity upon vaccination with protein antigen. In this issue of EMBO Molecular Medicine, a classical type of adjuvant made of DNA oligonucleotide containing CpG motifs, which has already been used in humans, is shown to boost humoral immunity primarily by acting on monocyte-derived dendritic cells. This study provides novel insight on the mode of action of adjuvant targeting Toll-like receptors.
format Online
Article
Text
id pubmed-4023880
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BlackWell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-40238802014-05-22 Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation Fillatreau, Simon EMBO Mol Med Closeups Adjuvants play an essential role in the induction of acquired immunity upon vaccination with protein antigen. In this issue of EMBO Molecular Medicine, a classical type of adjuvant made of DNA oligonucleotide containing CpG motifs, which has already been used in humans, is shown to boost humoral immunity primarily by acting on monocyte-derived dendritic cells. This study provides novel insight on the mode of action of adjuvant targeting Toll-like receptors. BlackWell Publishing Ltd 2014-05 2014-05-06 /pmc/articles/PMC4023880/ /pubmed/24803394 http://dx.doi.org/10.1002/emmm.201404015 Text en © 2014 The Author. Published under the terms of the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Closeups
Fillatreau, Simon
Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation
title Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation
title_full Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation
title_fullStr Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation
title_full_unstemmed Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation
title_short Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation
title_sort monocyte-derived dendritic cells identified as booster of t follicular helper cell differentiation
topic Closeups
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023880/
https://www.ncbi.nlm.nih.gov/pubmed/24803394
http://dx.doi.org/10.1002/emmm.201404015
work_keys_str_mv AT fillatreausimon monocytederiveddendriticcellsidentifiedasboosteroftfollicularhelpercelldifferentiation

Ejemplares similares