Calcium, Orai1 and Epidermal Proliferation

Ca(2+) influx controls essential epidermal functions, including proliferation, differentiation, cell migration, itch, and barrier homeostasis. The Orai1 ion channel allows capacitive Ca(2+) influx after Ca(2+) release from the endoplasmic reticulum, and it has now been shown to modulate epidermal at...

Descripción completa

Detalles Bibliográficos
Autores principales: Bikle, DD, Mauro, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023905/
https://www.ncbi.nlm.nih.gov/pubmed/24825060
http://dx.doi.org/10.1038/jid.2014.54
_version_ 1782316586488561664
author Bikle, DD
Mauro, T
author_facet Bikle, DD
Mauro, T
author_sort Bikle, DD
collection PubMed
description Ca(2+) influx controls essential epidermal functions, including proliferation, differentiation, cell migration, itch, and barrier homeostasis. The Orai1 ion channel allows capacitive Ca(2+) influx after Ca(2+) release from the endoplasmic reticulum, and it has now been shown to modulate epidermal atrophy. These findings reveal new interactions among various Ca(2+) signaling pathways and uncover novel functions for Ca(2+) signaling via the Orai1 channel.
format Online
Article
Text
id pubmed-4023905
institution National Center for Biotechnology Information
language English
publishDate 2014
record_format MEDLINE/PubMed
spelling pubmed-40239052014-12-01 Calcium, Orai1 and Epidermal Proliferation Bikle, DD Mauro, T J Invest Dermatol Article Ca(2+) influx controls essential epidermal functions, including proliferation, differentiation, cell migration, itch, and barrier homeostasis. The Orai1 ion channel allows capacitive Ca(2+) influx after Ca(2+) release from the endoplasmic reticulum, and it has now been shown to modulate epidermal atrophy. These findings reveal new interactions among various Ca(2+) signaling pathways and uncover novel functions for Ca(2+) signaling via the Orai1 channel. 2014-06 /pmc/articles/PMC4023905/ /pubmed/24825060 http://dx.doi.org/10.1038/jid.2014.54 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Bikle, DD
Mauro, T
Calcium, Orai1 and Epidermal Proliferation
title Calcium, Orai1 and Epidermal Proliferation
title_full Calcium, Orai1 and Epidermal Proliferation
title_fullStr Calcium, Orai1 and Epidermal Proliferation
title_full_unstemmed Calcium, Orai1 and Epidermal Proliferation
title_short Calcium, Orai1 and Epidermal Proliferation
title_sort calcium, orai1 and epidermal proliferation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023905/
https://www.ncbi.nlm.nih.gov/pubmed/24825060
http://dx.doi.org/10.1038/jid.2014.54
work_keys_str_mv AT bikledd calciumorai1andepidermalproliferation
AT maurot calciumorai1andepidermalproliferation

Ejemplares similares