Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder

Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 conditional knockout mouse model of CDKL5 disorder. B...

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Detalles Bibliográficos
Autores principales: Amendola, Elena, Zhan, Yang, Mattucci, Camilla, Castroflorio, Enrico, Calcagno, Eleonora, Fuchs, Claudia, Lonetti, Giuseppina, Silingardi, Davide, Vyssotski, Alexei L., Farley, Dominika, Ciani, Elisabetta, Pizzorusso, Tommaso, Giustetto, Maurizio, Gross, Cornelius T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023934/
https://www.ncbi.nlm.nih.gov/pubmed/24838000
http://dx.doi.org/10.1371/journal.pone.0091613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023934/
https://www.ncbi.nlm.nih.gov/pubmed/24838000
http://dx.doi.org/10.1371/journal.pone.0091613

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