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Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder

Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 conditional knockout mouse model of CDKL5 disorder. B...

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Detalles Bibliográficos
Autores principales:	Amendola, Elena, Zhan, Yang, Mattucci, Camilla, Castroflorio, Enrico, Calcagno, Eleonora, Fuchs, Claudia, Lonetti, Giuseppina, Silingardi, Davide, Vyssotski, Alexei L., Farley, Dominika, Ciani, Elisabetta, Pizzorusso, Tommaso, Giustetto, Maurizio, Gross, Cornelius T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023934/ https://www.ncbi.nlm.nih.gov/pubmed/24838000 http://dx.doi.org/10.1371/journal.pone.0091613

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