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Worm variation made accessible: Take your shopping cart to store, link, and investigate!
In Caenorhabditis elegans, the recent advances in high-throughput quantitative analyses of natural genetic and phenotypic variation have led to a wealth of data on genotype phenotype relations. This data has resulted in the discovery of genes with major allelic effects and insights in the effect of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024057/ https://www.ncbi.nlm.nih.gov/pubmed/24843834 http://dx.doi.org/10.4161/worm.28357 |
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author | Snoek, L Basten Joeri van der Velde, K Li, Yang Jansen, Ritsert C Swertz, Morris A Kammenga, Jan E |
author_facet | Snoek, L Basten Joeri van der Velde, K Li, Yang Jansen, Ritsert C Swertz, Morris A Kammenga, Jan E |
author_sort | Snoek, L Basten |
collection | PubMed |
description | In Caenorhabditis elegans, the recent advances in high-throughput quantitative analyses of natural genetic and phenotypic variation have led to a wealth of data on genotype phenotype relations. This data has resulted in the discovery of genes with major allelic effects and insights in the effect of natural genetic variation on a whole range of complex traits as well as how this variation is distributed across the genome. Regardless of the advances presented in specific studies, the majority of the data generated in these studies had yet to be made easily accessible, allowing for meta-analysis. Not only data in figures or tables but meta-data should be accessible for further investigation and comparison between studies. A platform was created where all the data, phenotypic measurements, genotypes, and mappings can be stored, compared, and new linkages within and between published studies can be discovered. WormQTL focuses on quantitative genetics in Caenorhabditis and other nematode species, whereas WormQTL(HD) quantitatively links gene expression quantitative trait loci (eQTL) in C. elegans to gene–disease associations in humans. |
format | Online Article Text |
id | pubmed-4024057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-40240572015-03-06 Worm variation made accessible: Take your shopping cart to store, link, and investigate! Snoek, L Basten Joeri van der Velde, K Li, Yang Jansen, Ritsert C Swertz, Morris A Kammenga, Jan E Worm Commentary In Caenorhabditis elegans, the recent advances in high-throughput quantitative analyses of natural genetic and phenotypic variation have led to a wealth of data on genotype phenotype relations. This data has resulted in the discovery of genes with major allelic effects and insights in the effect of natural genetic variation on a whole range of complex traits as well as how this variation is distributed across the genome. Regardless of the advances presented in specific studies, the majority of the data generated in these studies had yet to be made easily accessible, allowing for meta-analysis. Not only data in figures or tables but meta-data should be accessible for further investigation and comparison between studies. A platform was created where all the data, phenotypic measurements, genotypes, and mappings can be stored, compared, and new linkages within and between published studies can be discovered. WormQTL focuses on quantitative genetics in Caenorhabditis and other nematode species, whereas WormQTL(HD) quantitatively links gene expression quantitative trait loci (eQTL) in C. elegans to gene–disease associations in humans. Landes Bioscience 2014-03-06 /pmc/articles/PMC4024057/ /pubmed/24843834 http://dx.doi.org/10.4161/worm.28357 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Commentary Snoek, L Basten Joeri van der Velde, K Li, Yang Jansen, Ritsert C Swertz, Morris A Kammenga, Jan E Worm variation made accessible: Take your shopping cart to store, link, and investigate! |
title | Worm variation made accessible: Take your shopping cart to store, link, and investigate! |
title_full | Worm variation made accessible: Take your shopping cart to store, link, and investigate! |
title_fullStr | Worm variation made accessible: Take your shopping cart to store, link, and investigate! |
title_full_unstemmed | Worm variation made accessible: Take your shopping cart to store, link, and investigate! |
title_short | Worm variation made accessible: Take your shopping cart to store, link, and investigate! |
title_sort | worm variation made accessible: take your shopping cart to store, link, and investigate! |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024057/ https://www.ncbi.nlm.nih.gov/pubmed/24843834 http://dx.doi.org/10.4161/worm.28357 |
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