Caloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging

Immune responses wane during aging, posing challenges to the potential effectiveness of cancer immunotherapies. We previously demonstrated that in the context of a promising immunotherapeutic, OX40 agonist (αOX40), older animals exhibited impaired anti-tumor immune responses and diminished CD4 T cel...

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Detalles Bibliográficos
Autores principales: Farazi, Michelle, Nguyen, Justine, Goldufsky, Josef, Linnane, Stephanie, Lukaesko, Lisa, Weinberg, Andrew D., Ruby, Carl E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024137/
https://www.ncbi.nlm.nih.gov/pubmed/24682539
http://dx.doi.org/10.1007/s00262-014-1542-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024137/
https://www.ncbi.nlm.nih.gov/pubmed/24682539
http://dx.doi.org/10.1007/s00262-014-1542-y

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