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Caloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging
Immune responses wane during aging, posing challenges to the potential effectiveness of cancer immunotherapies. We previously demonstrated that in the context of a promising immunotherapeutic, OX40 agonist (αOX40), older animals exhibited impaired anti-tumor immune responses and diminished CD4 T cel...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024137/ https://www.ncbi.nlm.nih.gov/pubmed/24682539 http://dx.doi.org/10.1007/s00262-014-1542-y |