Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein

Glucokinase activity is a major determinant of hepatic glucose metabolism and blood glucose homeostasis. Liver glucokinase activity is regulated acutely by adaptive translocation between the nucleus and the cytoplasm through binding and dissociation from its regulatory protein (GKRP) in the nucleus....

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Detalles Bibliográficos
Autores principales: Cullen, Kirsty S., Al-Oanzi, Ziad H., O'Harte, Finbarr P.M., Agius, Loranne, Arden, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024195/
https://www.ncbi.nlm.nih.gov/pubmed/24566088
http://dx.doi.org/10.1016/j.bbamcr.2014.02.006

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