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Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies

INTRODUCTION: A single dose or short course of primaquine given to people infected with malaria may reduce transmission of Plasmodium falciparum through its effects on gametocytes. Primaquine is also known to cause haemolysis in people with variants of glucose-6-phosphate dehydrogenase (G6PD) defici...

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Autores principales: Uthman, Olalekan A, Saunders, Rachel, Sinclair, David, Graves, Patricia, Gelband, Hellen, Clarke, Aileen, Garner, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024606/
https://www.ncbi.nlm.nih.gov/pubmed/24833685
http://dx.doi.org/10.1136/bmjopen-2013-004664
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author Uthman, Olalekan A
Saunders, Rachel
Sinclair, David
Graves, Patricia
Gelband, Hellen
Clarke, Aileen
Garner, Paul
author_facet Uthman, Olalekan A
Saunders, Rachel
Sinclair, David
Graves, Patricia
Gelband, Hellen
Clarke, Aileen
Garner, Paul
author_sort Uthman, Olalekan A
collection PubMed
description INTRODUCTION: A single dose or short course of primaquine given to people infected with malaria may reduce transmission of Plasmodium falciparum through its effects on gametocytes. Primaquine is also known to cause haemolysis in people with variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency. The objective of this systematic review was to assess the risk of adverse effects in people with G6PD deficiency given primaquine or other 8-aminoquinoline (8AQ) as a single dose or short course (less than 7 days). METHODS AND ANALYSIS: We will search the following databases: Cochrane Infectious Diseases Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and LILACS. Prospective cohort studies, randomised and quasi-randomised trials that evaluated 8AQs for whatever reason in adults or children with a known G6PD deficiency will be included. Two authors will independently assess each study for eligibility, risk of bias and extract data. ETHICS AND DISSEMINATION: This systematic review will be published in a peer-reviewed journal. Brief reports of the review findings will be disseminated directly to the appropriate audiences and the WHO Technical Expert Group in Malaria Chemotherapy. As no primary data collection will be undertaken, no additional formal ethical assessment and informed consent are required. PROTOCOL REGISTRATION IN PROSPERO: The protocol is registered with PROSPERO, registration number CRD42013006518.
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spelling pubmed-40246062014-05-21 Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies Uthman, Olalekan A Saunders, Rachel Sinclair, David Graves, Patricia Gelband, Hellen Clarke, Aileen Garner, Paul BMJ Open Infectious Diseases INTRODUCTION: A single dose or short course of primaquine given to people infected with malaria may reduce transmission of Plasmodium falciparum through its effects on gametocytes. Primaquine is also known to cause haemolysis in people with variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency. The objective of this systematic review was to assess the risk of adverse effects in people with G6PD deficiency given primaquine or other 8-aminoquinoline (8AQ) as a single dose or short course (less than 7 days). METHODS AND ANALYSIS: We will search the following databases: Cochrane Infectious Diseases Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE and LILACS. Prospective cohort studies, randomised and quasi-randomised trials that evaluated 8AQs for whatever reason in adults or children with a known G6PD deficiency will be included. Two authors will independently assess each study for eligibility, risk of bias and extract data. ETHICS AND DISSEMINATION: This systematic review will be published in a peer-reviewed journal. Brief reports of the review findings will be disseminated directly to the appropriate audiences and the WHO Technical Expert Group in Malaria Chemotherapy. As no primary data collection will be undertaken, no additional formal ethical assessment and informed consent are required. PROTOCOL REGISTRATION IN PROSPERO: The protocol is registered with PROSPERO, registration number CRD42013006518. BMJ Publishing Group 2014-05-14 /pmc/articles/PMC4024606/ /pubmed/24833685 http://dx.doi.org/10.1136/bmjopen-2013-004664 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Infectious Diseases
Uthman, Olalekan A
Saunders, Rachel
Sinclair, David
Graves, Patricia
Gelband, Hellen
Clarke, Aileen
Garner, Paul
Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies
title Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies
title_full Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies
title_fullStr Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies
title_full_unstemmed Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies
title_short Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies
title_sort safety of 8-aminoquinolines given to people with g6pd deficiency: protocol for systematic review of prospective studies
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024606/
https://www.ncbi.nlm.nih.gov/pubmed/24833685
http://dx.doi.org/10.1136/bmjopen-2013-004664
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