Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

Mitochondrial function is an important determinant of the ageing process; however, the mitochondrial properties that enable longevity are not well understood. Here we show that optimal assembly of mitochondrial complex I predicts longevity in mice. Using an unbiased high-coverage high-confidence app...

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Detalles Bibliográficos
Autores principales: Miwa, Satomi, Jow, Howsun, Baty, Karen, Johnson, Amy, Czapiewski, Rafal, Saretzki, Gabriele, Treumann, Achim, von Zglinicki, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024759/
https://www.ncbi.nlm.nih.gov/pubmed/24815183
http://dx.doi.org/10.1038/ncomms4837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024759/
https://www.ncbi.nlm.nih.gov/pubmed/24815183
http://dx.doi.org/10.1038/ncomms4837

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