Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study

The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion criteria. For plasma tHcy concentration (µM/L), reference values (median [5-95 perce...

Descripción completa

Detalles Bibliográficos
Autores principales: Kweon, Sun-Seog, Lee, Young-Hoon, Jeong, Seul-Ki, Nam, Hae-Sung, Park, Kyeong-Soo, Choi, Seong-Woo, Kim, Bok-Hee, Kim, Hee Nam, Choi, Jin-Su, Shin, Min-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024951/
https://www.ncbi.nlm.nih.gov/pubmed/24851035
http://dx.doi.org/10.3346/jkms.2014.29.5.743
_version_ 1782316703707824128
author Kweon, Sun-Seog
Lee, Young-Hoon
Jeong, Seul-Ki
Nam, Hae-Sung
Park, Kyeong-Soo
Choi, Seong-Woo
Kim, Bok-Hee
Kim, Hee Nam
Choi, Jin-Su
Shin, Min-Ho
author_facet Kweon, Sun-Seog
Lee, Young-Hoon
Jeong, Seul-Ki
Nam, Hae-Sung
Park, Kyeong-Soo
Choi, Seong-Woo
Kim, Bok-Hee
Kim, Hee Nam
Choi, Jin-Su
Shin, Min-Ho
author_sort Kweon, Sun-Seog
collection PubMed
description The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion criteria. For plasma tHcy concentration (µM/L), reference values (median [5-95 percentile]) were 7.72 (5.03 to 13.80) and 6.09 (3.95-10.19) in men and women, respectively. For serum folate concentration (nM/L), reference values were 23.71 (11.73-38.44) and 28.95 (15.23-40.44) in men and women, respectively. The tHcy levels of both genders in the present study were lower than those in previous reports from other countries and Korea. GRAPHICAL ABSTRACT: [Image: see text]
format Online
Article
Text
id pubmed-4024951
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-40249512014-05-21 Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study Kweon, Sun-Seog Lee, Young-Hoon Jeong, Seul-Ki Nam, Hae-Sung Park, Kyeong-Soo Choi, Seong-Woo Kim, Bok-Hee Kim, Hee Nam Choi, Jin-Su Shin, Min-Ho J Korean Med Sci Brief Communication The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion criteria. For plasma tHcy concentration (µM/L), reference values (median [5-95 percentile]) were 7.72 (5.03 to 13.80) and 6.09 (3.95-10.19) in men and women, respectively. For serum folate concentration (nM/L), reference values were 23.71 (11.73-38.44) and 28.95 (15.23-40.44) in men and women, respectively. The tHcy levels of both genders in the present study were lower than those in previous reports from other countries and Korea. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2014-05 2014-04-25 /pmc/articles/PMC4024951/ /pubmed/24851035 http://dx.doi.org/10.3346/jkms.2014.29.5.743 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Kweon, Sun-Seog
Lee, Young-Hoon
Jeong, Seul-Ki
Nam, Hae-Sung
Park, Kyeong-Soo
Choi, Seong-Woo
Kim, Bok-Hee
Kim, Hee Nam
Choi, Jin-Su
Shin, Min-Ho
Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
title Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
title_full Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
title_fullStr Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
title_full_unstemmed Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
title_short Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
title_sort methylenetetrahydrofolate reductase 677 genotype-specific reference values for plasma homocysteine and serum folate concentrations in korean population aged 45 to 74 years: the namwon study
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024951/
https://www.ncbi.nlm.nih.gov/pubmed/24851035
http://dx.doi.org/10.3346/jkms.2014.29.5.743
work_keys_str_mv AT kweonsunseog methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy
AT leeyounghoon methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy
AT jeongseulki methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy
AT namhaesung methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy
AT parkkyeongsoo methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy
AT choiseongwoo methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy
AT kimbokhee methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy
AT kimheenam methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy
AT choijinsu methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy
AT shinminho methylenetetrahydrofolatereductase677genotypespecificreferencevaluesforplasmahomocysteineandserumfolateconcentrationsinkoreanpopulationaged45to74yearsthenamwonstudy

Ejemplares similares