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Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention

This study aimed to analyse the impact of obesity in type 2 diabetes (T2D) on adipocytokines (adiponectin, leptin and resistin) and inflammatory markers (TNF-α, IL-6 and hsCRP) as cardiovascular risk factors. A cross-sectional study comparing the basal levels of adipocytokines and inflammatory marke...

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Autores principales: Rajkovic, Natasa, Zamaklar, Miroslava, Lalic, Katarina, Jotic, Aleksandra, Lukic, Ljiljana, Milicic, Tanja, Singh, Sandra, Stosic, Ljubica, Lalic, Nebojsa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024989/
https://www.ncbi.nlm.nih.gov/pubmed/24736687
http://dx.doi.org/10.3390/ijerph110404049
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author Rajkovic, Natasa
Zamaklar, Miroslava
Lalic, Katarina
Jotic, Aleksandra
Lukic, Ljiljana
Milicic, Tanja
Singh, Sandra
Stosic, Ljubica
Lalic, Nebojsa M.
author_facet Rajkovic, Natasa
Zamaklar, Miroslava
Lalic, Katarina
Jotic, Aleksandra
Lukic, Ljiljana
Milicic, Tanja
Singh, Sandra
Stosic, Ljubica
Lalic, Nebojsa M.
author_sort Rajkovic, Natasa
collection PubMed
description This study aimed to analyse the impact of obesity in type 2 diabetes (T2D) on adipocytokines (adiponectin, leptin and resistin) and inflammatory markers (TNF-α, IL-6 and hsCRP) as cardiovascular risk factors. A cross-sectional study comparing the basal levels of adipocytokines and inflammatory markers was done in 18 obese (BMI ≥ 30 kg/m(2)) (group A), 21 overweight (25 kg/m(2 )≤ BMI < 30 kg/m(2)) (group B), 25 non-obese T2D patients (group C) and 15 non-obese controls (group D). The lowest levels of adiponectin and the highest levels of leptin, resistin, TNF-α, IL-6 and hsCRP were found in group A. Adiponectin levels were significantly lower, and resistin, TNF-α, and hsCRP levels were elevated in group C vs. D. However, leptin and IL-6 levels differed significantly between groups A and B, but not between groups C and D. Moreover, we found a significant negative correlation between adiponectin and TNF-α, but not with other markers, which was independent of the presence of obesity. In contrast, leptin and resistin correlated with the inflammatory markers, and this correlation was obesity-dependent. Our results suggest that obesity influences cardiovascular risk primarily through changes in leptin and resistin and less efficiently at the level of adiponectin.
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spelling pubmed-40249892014-05-19 Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention Rajkovic, Natasa Zamaklar, Miroslava Lalic, Katarina Jotic, Aleksandra Lukic, Ljiljana Milicic, Tanja Singh, Sandra Stosic, Ljubica Lalic, Nebojsa M. Int J Environ Res Public Health Article This study aimed to analyse the impact of obesity in type 2 diabetes (T2D) on adipocytokines (adiponectin, leptin and resistin) and inflammatory markers (TNF-α, IL-6 and hsCRP) as cardiovascular risk factors. A cross-sectional study comparing the basal levels of adipocytokines and inflammatory markers was done in 18 obese (BMI ≥ 30 kg/m(2)) (group A), 21 overweight (25 kg/m(2 )≤ BMI < 30 kg/m(2)) (group B), 25 non-obese T2D patients (group C) and 15 non-obese controls (group D). The lowest levels of adiponectin and the highest levels of leptin, resistin, TNF-α, IL-6 and hsCRP were found in group A. Adiponectin levels were significantly lower, and resistin, TNF-α, and hsCRP levels were elevated in group C vs. D. However, leptin and IL-6 levels differed significantly between groups A and B, but not between groups C and D. Moreover, we found a significant negative correlation between adiponectin and TNF-α, but not with other markers, which was independent of the presence of obesity. In contrast, leptin and resistin correlated with the inflammatory markers, and this correlation was obesity-dependent. Our results suggest that obesity influences cardiovascular risk primarily through changes in leptin and resistin and less efficiently at the level of adiponectin. MDPI 2014-04-14 2014-04 /pmc/articles/PMC4024989/ /pubmed/24736687 http://dx.doi.org/10.3390/ijerph110404049 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Rajkovic, Natasa
Zamaklar, Miroslava
Lalic, Katarina
Jotic, Aleksandra
Lukic, Ljiljana
Milicic, Tanja
Singh, Sandra
Stosic, Ljubica
Lalic, Nebojsa M.
Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention
title Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention
title_full Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention
title_fullStr Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention
title_full_unstemmed Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention
title_short Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention
title_sort relationship between obesity, adipocytokines and inflammatory markers in type 2 diabetes: relevance for cardiovascular risk prevention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024989/
https://www.ncbi.nlm.nih.gov/pubmed/24736687
http://dx.doi.org/10.3390/ijerph110404049
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