Cargando…
Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention
This study aimed to analyse the impact of obesity in type 2 diabetes (T2D) on adipocytokines (adiponectin, leptin and resistin) and inflammatory markers (TNF-α, IL-6 and hsCRP) as cardiovascular risk factors. A cross-sectional study comparing the basal levels of adipocytokines and inflammatory marke...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024989/ https://www.ncbi.nlm.nih.gov/pubmed/24736687 http://dx.doi.org/10.3390/ijerph110404049 |
_version_ | 1782316710533005312 |
---|---|
author | Rajkovic, Natasa Zamaklar, Miroslava Lalic, Katarina Jotic, Aleksandra Lukic, Ljiljana Milicic, Tanja Singh, Sandra Stosic, Ljubica Lalic, Nebojsa M. |
author_facet | Rajkovic, Natasa Zamaklar, Miroslava Lalic, Katarina Jotic, Aleksandra Lukic, Ljiljana Milicic, Tanja Singh, Sandra Stosic, Ljubica Lalic, Nebojsa M. |
author_sort | Rajkovic, Natasa |
collection | PubMed |
description | This study aimed to analyse the impact of obesity in type 2 diabetes (T2D) on adipocytokines (adiponectin, leptin and resistin) and inflammatory markers (TNF-α, IL-6 and hsCRP) as cardiovascular risk factors. A cross-sectional study comparing the basal levels of adipocytokines and inflammatory markers was done in 18 obese (BMI ≥ 30 kg/m(2)) (group A), 21 overweight (25 kg/m(2 )≤ BMI < 30 kg/m(2)) (group B), 25 non-obese T2D patients (group C) and 15 non-obese controls (group D). The lowest levels of adiponectin and the highest levels of leptin, resistin, TNF-α, IL-6 and hsCRP were found in group A. Adiponectin levels were significantly lower, and resistin, TNF-α, and hsCRP levels were elevated in group C vs. D. However, leptin and IL-6 levels differed significantly between groups A and B, but not between groups C and D. Moreover, we found a significant negative correlation between adiponectin and TNF-α, but not with other markers, which was independent of the presence of obesity. In contrast, leptin and resistin correlated with the inflammatory markers, and this correlation was obesity-dependent. Our results suggest that obesity influences cardiovascular risk primarily through changes in leptin and resistin and less efficiently at the level of adiponectin. |
format | Online Article Text |
id | pubmed-4024989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40249892014-05-19 Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention Rajkovic, Natasa Zamaklar, Miroslava Lalic, Katarina Jotic, Aleksandra Lukic, Ljiljana Milicic, Tanja Singh, Sandra Stosic, Ljubica Lalic, Nebojsa M. Int J Environ Res Public Health Article This study aimed to analyse the impact of obesity in type 2 diabetes (T2D) on adipocytokines (adiponectin, leptin and resistin) and inflammatory markers (TNF-α, IL-6 and hsCRP) as cardiovascular risk factors. A cross-sectional study comparing the basal levels of adipocytokines and inflammatory markers was done in 18 obese (BMI ≥ 30 kg/m(2)) (group A), 21 overweight (25 kg/m(2 )≤ BMI < 30 kg/m(2)) (group B), 25 non-obese T2D patients (group C) and 15 non-obese controls (group D). The lowest levels of adiponectin and the highest levels of leptin, resistin, TNF-α, IL-6 and hsCRP were found in group A. Adiponectin levels were significantly lower, and resistin, TNF-α, and hsCRP levels were elevated in group C vs. D. However, leptin and IL-6 levels differed significantly between groups A and B, but not between groups C and D. Moreover, we found a significant negative correlation between adiponectin and TNF-α, but not with other markers, which was independent of the presence of obesity. In contrast, leptin and resistin correlated with the inflammatory markers, and this correlation was obesity-dependent. Our results suggest that obesity influences cardiovascular risk primarily through changes in leptin and resistin and less efficiently at the level of adiponectin. MDPI 2014-04-14 2014-04 /pmc/articles/PMC4024989/ /pubmed/24736687 http://dx.doi.org/10.3390/ijerph110404049 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Rajkovic, Natasa Zamaklar, Miroslava Lalic, Katarina Jotic, Aleksandra Lukic, Ljiljana Milicic, Tanja Singh, Sandra Stosic, Ljubica Lalic, Nebojsa M. Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention |
title | Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention |
title_full | Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention |
title_fullStr | Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention |
title_full_unstemmed | Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention |
title_short | Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention |
title_sort | relationship between obesity, adipocytokines and inflammatory markers in type 2 diabetes: relevance for cardiovascular risk prevention |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024989/ https://www.ncbi.nlm.nih.gov/pubmed/24736687 http://dx.doi.org/10.3390/ijerph110404049 |
work_keys_str_mv | AT rajkovicnatasa relationshipbetweenobesityadipocytokinesandinflammatorymarkersintype2diabetesrelevanceforcardiovascularriskprevention AT zamaklarmiroslava relationshipbetweenobesityadipocytokinesandinflammatorymarkersintype2diabetesrelevanceforcardiovascularriskprevention AT lalickatarina relationshipbetweenobesityadipocytokinesandinflammatorymarkersintype2diabetesrelevanceforcardiovascularriskprevention AT joticaleksandra relationshipbetweenobesityadipocytokinesandinflammatorymarkersintype2diabetesrelevanceforcardiovascularriskprevention AT lukicljiljana relationshipbetweenobesityadipocytokinesandinflammatorymarkersintype2diabetesrelevanceforcardiovascularriskprevention AT milicictanja relationshipbetweenobesityadipocytokinesandinflammatorymarkersintype2diabetesrelevanceforcardiovascularriskprevention AT singhsandra relationshipbetweenobesityadipocytokinesandinflammatorymarkersintype2diabetesrelevanceforcardiovascularriskprevention AT stosicljubica relationshipbetweenobesityadipocytokinesandinflammatorymarkersintype2diabetesrelevanceforcardiovascularriskprevention AT lalicnebojsam relationshipbetweenobesityadipocytokinesandinflammatorymarkersintype2diabetesrelevanceforcardiovascularriskprevention |