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Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan
Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study co...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025040/ https://www.ncbi.nlm.nih.gov/pubmed/24705358 http://dx.doi.org/10.3390/ijerph110403705 |
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author | Kuo, Ho-Chang Wu, Chung-Min Chang, Wei-Pin Kuo, Chun-Nan Yeter, Deniz Lin, Chun-Yi Pai, Jei-Tsung Chi, Ying-Chen Lin, Chia-Hsien Wang, Liang-Jen Chang, Wei-Chiao |
author_facet | Kuo, Ho-Chang Wu, Chung-Min Chang, Wei-Pin Kuo, Chun-Nan Yeter, Deniz Lin, Chun-Yi Pai, Jei-Tsung Chi, Ying-Chen Lin, Chia-Hsien Wang, Liang-Jen Chang, Wei-Chiao |
author_sort | Kuo, Ho-Chang |
collection | PubMed |
description | Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age- and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2,815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates. Results: The main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95% confidence interval: 0.68–34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up. Conclusion: Our study indicated that patients with Kawasaki disease are not at increased risk of autism. |
format | Online Article Text |
id | pubmed-4025040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40250402014-05-19 Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan Kuo, Ho-Chang Wu, Chung-Min Chang, Wei-Pin Kuo, Chun-Nan Yeter, Deniz Lin, Chun-Yi Pai, Jei-Tsung Chi, Ying-Chen Lin, Chia-Hsien Wang, Liang-Jen Chang, Wei-Chiao Int J Environ Res Public Health Article Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age- and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2,815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates. Results: The main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95% confidence interval: 0.68–34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up. Conclusion: Our study indicated that patients with Kawasaki disease are not at increased risk of autism. MDPI 2014-04-03 2014-04 /pmc/articles/PMC4025040/ /pubmed/24705358 http://dx.doi.org/10.3390/ijerph110403705 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Kuo, Ho-Chang Wu, Chung-Min Chang, Wei-Pin Kuo, Chun-Nan Yeter, Deniz Lin, Chun-Yi Pai, Jei-Tsung Chi, Ying-Chen Lin, Chia-Hsien Wang, Liang-Jen Chang, Wei-Chiao Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan |
title | Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan |
title_full | Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan |
title_fullStr | Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan |
title_full_unstemmed | Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan |
title_short | Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan |
title_sort | association between kawasaki disease and autism: a population-based study in taiwan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025040/ https://www.ncbi.nlm.nih.gov/pubmed/24705358 http://dx.doi.org/10.3390/ijerph110403705 |
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