Cargando…

Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan

Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study co...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuo, Ho-Chang, Wu, Chung-Min, Chang, Wei-Pin, Kuo, Chun-Nan, Yeter, Deniz, Lin, Chun-Yi, Pai, Jei-Tsung, Chi, Ying-Chen, Lin, Chia-Hsien, Wang, Liang-Jen, Chang, Wei-Chiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025040/
https://www.ncbi.nlm.nih.gov/pubmed/24705358
http://dx.doi.org/10.3390/ijerph110403705
_version_ 1782316722156470272
author Kuo, Ho-Chang
Wu, Chung-Min
Chang, Wei-Pin
Kuo, Chun-Nan
Yeter, Deniz
Lin, Chun-Yi
Pai, Jei-Tsung
Chi, Ying-Chen
Lin, Chia-Hsien
Wang, Liang-Jen
Chang, Wei-Chiao
author_facet Kuo, Ho-Chang
Wu, Chung-Min
Chang, Wei-Pin
Kuo, Chun-Nan
Yeter, Deniz
Lin, Chun-Yi
Pai, Jei-Tsung
Chi, Ying-Chen
Lin, Chia-Hsien
Wang, Liang-Jen
Chang, Wei-Chiao
author_sort Kuo, Ho-Chang
collection PubMed
description Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age- and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2,815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates. Results: The main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95% confidence interval: 0.68–34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up. Conclusion: Our study indicated that patients with Kawasaki disease are not at increased risk of autism.
format Online
Article
Text
id pubmed-4025040
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-40250402014-05-19 Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan Kuo, Ho-Chang Wu, Chung-Min Chang, Wei-Pin Kuo, Chun-Nan Yeter, Deniz Lin, Chun-Yi Pai, Jei-Tsung Chi, Ying-Chen Lin, Chia-Hsien Wang, Liang-Jen Chang, Wei-Chiao Int J Environ Res Public Health Article Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age- and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2,815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates. Results: The main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95% confidence interval: 0.68–34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up. Conclusion: Our study indicated that patients with Kawasaki disease are not at increased risk of autism. MDPI 2014-04-03 2014-04 /pmc/articles/PMC4025040/ /pubmed/24705358 http://dx.doi.org/10.3390/ijerph110403705 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kuo, Ho-Chang
Wu, Chung-Min
Chang, Wei-Pin
Kuo, Chun-Nan
Yeter, Deniz
Lin, Chun-Yi
Pai, Jei-Tsung
Chi, Ying-Chen
Lin, Chia-Hsien
Wang, Liang-Jen
Chang, Wei-Chiao
Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan
title Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan
title_full Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan
title_fullStr Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan
title_full_unstemmed Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan
title_short Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan
title_sort association between kawasaki disease and autism: a population-based study in taiwan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025040/
https://www.ncbi.nlm.nih.gov/pubmed/24705358
http://dx.doi.org/10.3390/ijerph110403705
work_keys_str_mv AT kuohochang associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT wuchungmin associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT changweipin associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT kuochunnan associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT yeterdeniz associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT linchunyi associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT paijeitsung associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT chiyingchen associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT linchiahsien associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT wangliangjen associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan
AT changweichiao associationbetweenkawasakidiseaseandautismapopulationbasedstudyintaiwan