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Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis

AIMS/INTRODUCTION: The aim of the present study was to investigate whether non‐surgical periodontal treatment reduces glycated hemoglobin (HbA(1c)) and fasting plasma glucose (FPG) levels in diabetic patients. MATERIALS AND METHODS: An electronic search was carried out on MEDLINE (through PubMed int...

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Autores principales: Corbella, Stefano, Francetti, Luca, Taschieri, Silvio, De Siena, Francesca, Fabbro, Massimo Del
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-Blackwell 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025114/
https://www.ncbi.nlm.nih.gov/pubmed/24843701
http://dx.doi.org/10.1111/jdi.12088
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author Corbella, Stefano
Francetti, Luca
Taschieri, Silvio
De Siena, Francesca
Fabbro, Massimo Del
author_facet Corbella, Stefano
Francetti, Luca
Taschieri, Silvio
De Siena, Francesca
Fabbro, Massimo Del
author_sort Corbella, Stefano
collection PubMed
description AIMS/INTRODUCTION: The aim of the present study was to investigate whether non‐surgical periodontal treatment reduces glycated hemoglobin (HbA(1c)) and fasting plasma glucose (FPG) levels in diabetic patients. MATERIALS AND METHODS: An electronic search was carried out on MEDLINE (through PubMed interface), EMBASE and the Cochrane Central Register of Controlled Trials. Randomized controlled trials with a minimum of 3 months follow up were included. The risk of bias was assessed for each study. A meta‐analysis was carried out to evaluate the effect of non‐surgical periodontal treatment on HbA(1c) and FPG levels. The effect of the adjunctive use of antimicrobials was also assessed. RESULTS: A total of 15 studies were included. A reduction of −0.38% (95% confidence interval [CI] −0.23 to −0.53) after 3–4 months (P < 0.001) and of −0.31% (95% CI 0.11 to −0.74) after 6 months (P = 0.15) of follow‐up was found for HbA(1c), favoring the treatment group. Similarly, in treated patients, a significantly greater decrease in FPG was observed in respect to control participants. Such difference amounted to −9.01 mg/dL (95% CI −2.24 to −15.78) after 3–4 months (P = 0.009) and −13.62 mg/dL (95% CI 0.45 to −27.69) after 6 months (P = 0.06) from treatment, respectively. In participants treated with adjunctive antimicrobials, a non‐significant increase of HbA(1c) was observed 3 months after treatment, whereas FPG decreased by 0.27 mg/dL (95% CI 39.56 to −40.11; P = 0.99). CONCLUSIONS: The meta‐analysis showed that non‐surgical periodontal treatment improves metabolic control in patients with both periodontitis and diabetes.
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spelling pubmed-40251142014-05-19 Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis Corbella, Stefano Francetti, Luca Taschieri, Silvio De Siena, Francesca Fabbro, Massimo Del J Diabetes Investig Articles AIMS/INTRODUCTION: The aim of the present study was to investigate whether non‐surgical periodontal treatment reduces glycated hemoglobin (HbA(1c)) and fasting plasma glucose (FPG) levels in diabetic patients. MATERIALS AND METHODS: An electronic search was carried out on MEDLINE (through PubMed interface), EMBASE and the Cochrane Central Register of Controlled Trials. Randomized controlled trials with a minimum of 3 months follow up were included. The risk of bias was assessed for each study. A meta‐analysis was carried out to evaluate the effect of non‐surgical periodontal treatment on HbA(1c) and FPG levels. The effect of the adjunctive use of antimicrobials was also assessed. RESULTS: A total of 15 studies were included. A reduction of −0.38% (95% confidence interval [CI] −0.23 to −0.53) after 3–4 months (P < 0.001) and of −0.31% (95% CI 0.11 to −0.74) after 6 months (P = 0.15) of follow‐up was found for HbA(1c), favoring the treatment group. Similarly, in treated patients, a significantly greater decrease in FPG was observed in respect to control participants. Such difference amounted to −9.01 mg/dL (95% CI −2.24 to −15.78) after 3–4 months (P = 0.009) and −13.62 mg/dL (95% CI 0.45 to −27.69) after 6 months (P = 0.06) from treatment, respectively. In participants treated with adjunctive antimicrobials, a non‐significant increase of HbA(1c) was observed 3 months after treatment, whereas FPG decreased by 0.27 mg/dL (95% CI 39.56 to −40.11; P = 0.99). CONCLUSIONS: The meta‐analysis showed that non‐surgical periodontal treatment improves metabolic control in patients with both periodontitis and diabetes. Wiley-Blackwell 2013-09-13 2013-04-18 /pmc/articles/PMC4025114/ /pubmed/24843701 http://dx.doi.org/10.1111/jdi.12088 Text en Copyright © 2013 Asian Association for the Study of Diabetes and Wiley Publishing Asia Pty Ltd
spellingShingle Articles
Corbella, Stefano
Francetti, Luca
Taschieri, Silvio
De Siena, Francesca
Fabbro, Massimo Del
Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis
title Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis
title_full Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis
title_fullStr Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis
title_full_unstemmed Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis
title_short Effect of periodontal treatment on glycemic control of patients with diabetes: A systematic review and meta‐analysis
title_sort effect of periodontal treatment on glycemic control of patients with diabetes: a systematic review and meta‐analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025114/
https://www.ncbi.nlm.nih.gov/pubmed/24843701
http://dx.doi.org/10.1111/jdi.12088
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