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Primary squamous cell carcinoma of the external auditory canal: surgical treatment and long-term outcomes

This study was conducted on patients with squamous cell carcinoma of the external auditory canal and temporal bone treated with surgery alone or surgery plus postoperative radiotherapy. It was designed as a retrospective investigation with complete long-term follow-up covering the years from 1983 to...

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Autores principales: MAZZONI, A., DANESI, G., ZANOLETTI, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore SpA 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025180/
https://www.ncbi.nlm.nih.gov/pubmed/24843224
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author MAZZONI, A.
DANESI, G.
ZANOLETTI, E.
author_facet MAZZONI, A.
DANESI, G.
ZANOLETTI, E.
author_sort MAZZONI, A.
collection PubMed
description This study was conducted on patients with squamous cell carcinoma of the external auditory canal and temporal bone treated with surgery alone or surgery plus postoperative radiotherapy. It was designed as a retrospective investigation with complete long-term follow-up covering the years from 1983 to 2008. The setting was a tertiary referral centre. Forty-one consecutive cases underwent surgery involving en bloc lateral or subtotal temporal bone resection, parotidectomy and neck dissection plus radiotherapy in advanced cases. The Pittsburgh staging system 7 was adopted. No cases were lost to follow-up, which ranged from 2 to 220 months, while for survivors ranged from 60 to 220 months and included clinical examinations and imaging. Outcome was expressed as NED (no evidence of disease), DOC (dead of other causes), DOD (dead of disease), AWD (alive with disease), disease-free survival (DFS) and disease-specific survival (DSS). Results were expressed with raw data and Kaplan Meyer curves. Patients with T1 and T2 disease had a DFS of 67% and a DSS of 92%. For T3 and T4 cases, the DFS was 41% and DSS was 48%. All treatment failures were due to local recurrences. The cases classified as T4 because the lesion extended from the cartilage canal to the periauricular soft tissues, or from the anterior wall to the parotid space, had a better outcome than the other T4 cases: this different prognosis suggests the need to stage tumours differently. Nodal disease coincided with a worse outcome due to local recurrence.
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spelling pubmed-40251802014-05-19 Primary squamous cell carcinoma of the external auditory canal: surgical treatment and long-term outcomes MAZZONI, A. DANESI, G. ZANOLETTI, E. Acta Otorhinolaryngol Ital Otology This study was conducted on patients with squamous cell carcinoma of the external auditory canal and temporal bone treated with surgery alone or surgery plus postoperative radiotherapy. It was designed as a retrospective investigation with complete long-term follow-up covering the years from 1983 to 2008. The setting was a tertiary referral centre. Forty-one consecutive cases underwent surgery involving en bloc lateral or subtotal temporal bone resection, parotidectomy and neck dissection plus radiotherapy in advanced cases. The Pittsburgh staging system 7 was adopted. No cases were lost to follow-up, which ranged from 2 to 220 months, while for survivors ranged from 60 to 220 months and included clinical examinations and imaging. Outcome was expressed as NED (no evidence of disease), DOC (dead of other causes), DOD (dead of disease), AWD (alive with disease), disease-free survival (DFS) and disease-specific survival (DSS). Results were expressed with raw data and Kaplan Meyer curves. Patients with T1 and T2 disease had a DFS of 67% and a DSS of 92%. For T3 and T4 cases, the DFS was 41% and DSS was 48%. All treatment failures were due to local recurrences. The cases classified as T4 because the lesion extended from the cartilage canal to the periauricular soft tissues, or from the anterior wall to the parotid space, had a better outcome than the other T4 cases: this different prognosis suggests the need to stage tumours differently. Nodal disease coincided with a worse outcome due to local recurrence. Pacini Editore SpA 2014-04 /pmc/articles/PMC4025180/ /pubmed/24843224 Text en © Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Otology
MAZZONI, A.
DANESI, G.
ZANOLETTI, E.
Primary squamous cell carcinoma of the external auditory canal: surgical treatment and long-term outcomes
title Primary squamous cell carcinoma of the external auditory canal: surgical treatment and long-term outcomes
title_full Primary squamous cell carcinoma of the external auditory canal: surgical treatment and long-term outcomes
title_fullStr Primary squamous cell carcinoma of the external auditory canal: surgical treatment and long-term outcomes
title_full_unstemmed Primary squamous cell carcinoma of the external auditory canal: surgical treatment and long-term outcomes
title_short Primary squamous cell carcinoma of the external auditory canal: surgical treatment and long-term outcomes
title_sort primary squamous cell carcinoma of the external auditory canal: surgical treatment and long-term outcomes
topic Otology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025180/
https://www.ncbi.nlm.nih.gov/pubmed/24843224
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