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Role of insulin receptor substrate‐1 for diethylnitrosamine plus high‐fat diet‐induced hepatic tumorigenesis in mice

We investigated the role of insulin receptor substrate (Irs)‐1 for diethylnitrosamine (DEN) plus high‐fat (HF) diet‐induced hepatic tumorigenesis in mice. We gave DEN by intraperitoneal injection at the dose of 80 mg/kg to 18‐week‐old wild‐type (WT) and Irs1‐knockout (Irs1(−/−)) mice, which were fed...

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Detalles Bibliográficos
Autores principales:	Zolzaya, Khadbaatar, Nakamura, Akinobu, Tajima, Kazuki, Terauchi, Yasuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley-Blackwell 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025237/ https://www.ncbi.nlm.nih.gov/pubmed/24843733 http://dx.doi.org/10.1111/jdi.12128

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