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Effects of interventions on adiponectin and adiponectin receptors
Adiponectin secreted from adipose tissue binds to two distinct adiponectin receptors (AdipoR1 and AdipoR2) identified and exerts its anti-diabetic effects in insulin-sensitive organs including liver, skeletal muscle and adipose tissue as well as amelioration of vascular dysfunction in the various va...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Exercise Rehabilitation
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025551/ https://www.ncbi.nlm.nih.gov/pubmed/24877039 http://dx.doi.org/10.12965/jer.140104 |
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author | Lee, Sewon Kwak, Hyo-Bum |
author_facet | Lee, Sewon Kwak, Hyo-Bum |
author_sort | Lee, Sewon |
collection | PubMed |
description | Adiponectin secreted from adipose tissue binds to two distinct adiponectin receptors (AdipoR1 and AdipoR2) identified and exerts its anti-diabetic effects in insulin-sensitive organs including liver, skeletal muscle and adipose tissue as well as amelioration of vascular dysfunction in the various vasculatures. A number of experimental and clinical observations have demonstrated that circulating levels of adiponectin are markedly reduced in obesity, type 2 diabetes, hypertension, and coronary artery disease. Therapeutic interventions which can improve the action of adiponectin including elevation of circulating adiponectin concentration or up-regulation and/or activation of its receptors, could provide better understanding of strategies to ameliorate metabolic disorders and vascular disease. The focus of the present review is to summarize accumulating evidence showing the role of interventions such as pharmacological agents, exercise, and calorie restriction in the expression of adiponectin and adiponectin receptors. |
format | Online Article Text |
id | pubmed-4025551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Society of Exercise Rehabilitation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40255512014-05-29 Effects of interventions on adiponectin and adiponectin receptors Lee, Sewon Kwak, Hyo-Bum J Exerc Rehabil Review Article Adiponectin secreted from adipose tissue binds to two distinct adiponectin receptors (AdipoR1 and AdipoR2) identified and exerts its anti-diabetic effects in insulin-sensitive organs including liver, skeletal muscle and adipose tissue as well as amelioration of vascular dysfunction in the various vasculatures. A number of experimental and clinical observations have demonstrated that circulating levels of adiponectin are markedly reduced in obesity, type 2 diabetes, hypertension, and coronary artery disease. Therapeutic interventions which can improve the action of adiponectin including elevation of circulating adiponectin concentration or up-regulation and/or activation of its receptors, could provide better understanding of strategies to ameliorate metabolic disorders and vascular disease. The focus of the present review is to summarize accumulating evidence showing the role of interventions such as pharmacological agents, exercise, and calorie restriction in the expression of adiponectin and adiponectin receptors. Korean Society of Exercise Rehabilitation 2014-04-30 /pmc/articles/PMC4025551/ /pubmed/24877039 http://dx.doi.org/10.12965/jer.140104 Text en Copyright © 2014 Korean Society of Exercise Rehabilitation This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lee, Sewon Kwak, Hyo-Bum Effects of interventions on adiponectin and adiponectin receptors |
title | Effects of interventions on adiponectin and adiponectin receptors |
title_full | Effects of interventions on adiponectin and adiponectin receptors |
title_fullStr | Effects of interventions on adiponectin and adiponectin receptors |
title_full_unstemmed | Effects of interventions on adiponectin and adiponectin receptors |
title_short | Effects of interventions on adiponectin and adiponectin receptors |
title_sort | effects of interventions on adiponectin and adiponectin receptors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025551/ https://www.ncbi.nlm.nih.gov/pubmed/24877039 http://dx.doi.org/10.12965/jer.140104 |
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