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Mechanistic and Bioinformatic Investigation of a Conserved Active Site Helix in α-Isopropylmalate Synthase from Mycobacterium tuberculosis, a Member of the DRE-TIM Metallolyase Superfamily

[Image: see text] The characterization of functionally diverse enzyme superfamilies provides the opportunity to identify evolutionarily conserved catalytic strategies, as well as amino acid substitutions responsible for the evolution of new functions or specificities. Isopropylmalate synthase (IPMS)...

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Detalles Bibliográficos
Autores principales:	Casey, Ashley K., Hicks, Michael A., Johnson, Jordyn L., Babbitt, Patricia C., Frantom, Patrick A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025573/ https://www.ncbi.nlm.nih.gov/pubmed/24720347 http://dx.doi.org/10.1021/bi500246z

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