Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures

CONCLUSION: Inhibition of thioredoxin reductase (TrxR) may be a contributing factor in cisplatin-induced ototoxicity. Direct exposure of organ of Corti to cisplatin and oxaliplatin gives equal loss of hair cells. OBJECTIVES: Platinum-containing drugs are known to target the anti-oxidant selenoprotei...

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Detalles Bibliográficos
Autores principales: Dammeyer, Pascal, Hellberg, Victoria, Wallin, Inger, Laurell, Göran, Shoshan, Maria, Ehrsson, Hans, Arnér, Elias S.J., Kirkegaard, Mette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025594/
https://www.ncbi.nlm.nih.gov/pubmed/24702224
http://dx.doi.org/10.3109/00016489.2013.879740

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