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A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients
Although several models have been developed to predict the probability of Gleason sum upgrading between biopsy and radical prostatectomy specimens, most of these models are restricted to prostate-specific antigen screening-detected prostate cancer. This study aimed to build a nomogram for the predic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sun Yat-sen University Cancer Center
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026544/ https://www.ncbi.nlm.nih.gov/pubmed/24559852 http://dx.doi.org/10.5732/cjc.013.10137 |
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author | Wang, Jin-You Zhu, Yao Wang, Chao-Fu Zhang, Shi-Lin Dai, Bo Ye, Ding-Wei |
author_facet | Wang, Jin-You Zhu, Yao Wang, Chao-Fu Zhang, Shi-Lin Dai, Bo Ye, Ding-Wei |
author_sort | Wang, Jin-You |
collection | PubMed |
description | Although several models have been developed to predict the probability of Gleason sum upgrading between biopsy and radical prostatectomy specimens, most of these models are restricted to prostate-specific antigen screening-detected prostate cancer. This study aimed to build a nomogram for the prediction of Gleason sum upgrading in clinically diagnosed prostate cancer. The study cohort comprised 269 Chinese prostate cancer patients who underwent prostate biopsy with a minimum of 10 cores and were subsequently treated with radical prostatectomy. Of all included patients, 220 (81.8%) were referred with clinical symptoms. The prostate-specific antigen level, primary and secondary biopsy Gleason scores, and clinical T category were used in a multivariate logistic regression model to predict the probability of Gleason sum upgrading. The developed nomogram was validated internally. Gleason sum upgrading was observed in 90 (33.5%) patients. Our nomogram showed a bootstrap-corrected concordance index of 0.789 and good calibration using 4 readily available variables. The nomogram also demonstrated satisfactory statistical performance for predicting significant upgrading. External validation of the nomogram published by Chun et al. in our cohort showed a marked discordance between the observed and predicted probabilities of Gleason sum upgrading. In summary, a new nomogram to predict Gleason sum upgrading in clinically diagnosed prostate cancer was developed, and it demonstrated good statistical performance upon internal validation. |
format | Online Article Text |
id | pubmed-4026544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sun Yat-sen University Cancer Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-40265442014-05-20 A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients Wang, Jin-You Zhu, Yao Wang, Chao-Fu Zhang, Shi-Lin Dai, Bo Ye, Ding-Wei Chin J Cancer Original Article Although several models have been developed to predict the probability of Gleason sum upgrading between biopsy and radical prostatectomy specimens, most of these models are restricted to prostate-specific antigen screening-detected prostate cancer. This study aimed to build a nomogram for the prediction of Gleason sum upgrading in clinically diagnosed prostate cancer. The study cohort comprised 269 Chinese prostate cancer patients who underwent prostate biopsy with a minimum of 10 cores and were subsequently treated with radical prostatectomy. Of all included patients, 220 (81.8%) were referred with clinical symptoms. The prostate-specific antigen level, primary and secondary biopsy Gleason scores, and clinical T category were used in a multivariate logistic regression model to predict the probability of Gleason sum upgrading. The developed nomogram was validated internally. Gleason sum upgrading was observed in 90 (33.5%) patients. Our nomogram showed a bootstrap-corrected concordance index of 0.789 and good calibration using 4 readily available variables. The nomogram also demonstrated satisfactory statistical performance for predicting significant upgrading. External validation of the nomogram published by Chun et al. in our cohort showed a marked discordance between the observed and predicted probabilities of Gleason sum upgrading. In summary, a new nomogram to predict Gleason sum upgrading in clinically diagnosed prostate cancer was developed, and it demonstrated good statistical performance upon internal validation. Sun Yat-sen University Cancer Center 2014-05 /pmc/articles/PMC4026544/ /pubmed/24559852 http://dx.doi.org/10.5732/cjc.013.10137 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Original Article Wang, Jin-You Zhu, Yao Wang, Chao-Fu Zhang, Shi-Lin Dai, Bo Ye, Ding-Wei A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients |
title | A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients |
title_full | A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients |
title_fullStr | A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients |
title_full_unstemmed | A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients |
title_short | A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients |
title_sort | nomogram to predict gleason sum upgrading of clinically diagnosed localized prostate cancer among chinese patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026544/ https://www.ncbi.nlm.nih.gov/pubmed/24559852 http://dx.doi.org/10.5732/cjc.013.10137 |
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