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External validation of nomograms for predicting cancer-specific mortality in penile cancer patients treated with definitive surgery
Using a population-based cancer registry, Thuret et al. developed 3 nomograms for estimating cancer-specific mortality in men with penile squamous cell carcinoma. In the initial cohort, only 23.0% of the patients were treated with inguinal lymphadenectomy and had pN stage. To generalize the predicti...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sun Yat-sen University Cancer Center
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026545/ https://www.ncbi.nlm.nih.gov/pubmed/24559854 http://dx.doi.org/10.5732/cjc.013.10176 |
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author | Zhu, Yao Gu, Wei-Jie Ye, Ding-Wei Yao, Xu-Dong Zhang, Shi-Lin Dai, Bo Zhang, Hai-Liang Shen, Yi-Jun |
author_facet | Zhu, Yao Gu, Wei-Jie Ye, Ding-Wei Yao, Xu-Dong Zhang, Shi-Lin Dai, Bo Zhang, Hai-Liang Shen, Yi-Jun |
author_sort | Zhu, Yao |
collection | PubMed |
description | Using a population-based cancer registry, Thuret et al. developed 3 nomograms for estimating cancer-specific mortality in men with penile squamous cell carcinoma. In the initial cohort, only 23.0% of the patients were treated with inguinal lymphadenectomy and had pN stage. To generalize the prediction models in clinical practice, we evaluated the performance of the 3 nomograms in a series of penile cancer patients who were treated with definitive surgery. Clinicopathologic information was obtained from 160 M0 penile cancer patients who underwent primary tumor excision and regional lymphadenectomy between 1990 and 2008. The predicted probabilities of cancer-specific mortality were calculated from 3 nomograms that were based on different disease stage definitions and tumor grade. Discrimination, calibration, and clinical usefulness were assessed to compare model performance. The discrimination ability was similar in nomograms using the TNM classification or American Joint Committee on Cancer staging (Harrell's concordance index = 0.817 and 0.832, respectively), whereas it was inferior for the Surveillance, Epidemiology and End Results staging (Harrell's concordance index = 0.728). Better agreement with the observed cancer-specific mortality was shown for the model consisting of TNM classification and tumor grade, which also achieved favorable clinical net benefit, with a threshold probability in the range of 0 to 42%. The nomogram consisting of TNM classification and tumor grading was shown to have better performance for predicting cancer-specific mortality in penile cancer patients who underwent definitive surgery. Our data support the integration of this model in decision-making and trial design. |
format | Online Article Text |
id | pubmed-4026545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sun Yat-sen University Cancer Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-40265452014-05-20 External validation of nomograms for predicting cancer-specific mortality in penile cancer patients treated with definitive surgery Zhu, Yao Gu, Wei-Jie Ye, Ding-Wei Yao, Xu-Dong Zhang, Shi-Lin Dai, Bo Zhang, Hai-Liang Shen, Yi-Jun Chin J Cancer Original Article Using a population-based cancer registry, Thuret et al. developed 3 nomograms for estimating cancer-specific mortality in men with penile squamous cell carcinoma. In the initial cohort, only 23.0% of the patients were treated with inguinal lymphadenectomy and had pN stage. To generalize the prediction models in clinical practice, we evaluated the performance of the 3 nomograms in a series of penile cancer patients who were treated with definitive surgery. Clinicopathologic information was obtained from 160 M0 penile cancer patients who underwent primary tumor excision and regional lymphadenectomy between 1990 and 2008. The predicted probabilities of cancer-specific mortality were calculated from 3 nomograms that were based on different disease stage definitions and tumor grade. Discrimination, calibration, and clinical usefulness were assessed to compare model performance. The discrimination ability was similar in nomograms using the TNM classification or American Joint Committee on Cancer staging (Harrell's concordance index = 0.817 and 0.832, respectively), whereas it was inferior for the Surveillance, Epidemiology and End Results staging (Harrell's concordance index = 0.728). Better agreement with the observed cancer-specific mortality was shown for the model consisting of TNM classification and tumor grade, which also achieved favorable clinical net benefit, with a threshold probability in the range of 0 to 42%. The nomogram consisting of TNM classification and tumor grading was shown to have better performance for predicting cancer-specific mortality in penile cancer patients who underwent definitive surgery. Our data support the integration of this model in decision-making and trial design. Sun Yat-sen University Cancer Center 2014-05 /pmc/articles/PMC4026545/ /pubmed/24559854 http://dx.doi.org/10.5732/cjc.013.10176 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Original Article Zhu, Yao Gu, Wei-Jie Ye, Ding-Wei Yao, Xu-Dong Zhang, Shi-Lin Dai, Bo Zhang, Hai-Liang Shen, Yi-Jun External validation of nomograms for predicting cancer-specific mortality in penile cancer patients treated with definitive surgery |
title | External validation of nomograms for predicting cancer-specific mortality in penile cancer patients treated with definitive surgery |
title_full | External validation of nomograms for predicting cancer-specific mortality in penile cancer patients treated with definitive surgery |
title_fullStr | External validation of nomograms for predicting cancer-specific mortality in penile cancer patients treated with definitive surgery |
title_full_unstemmed | External validation of nomograms for predicting cancer-specific mortality in penile cancer patients treated with definitive surgery |
title_short | External validation of nomograms for predicting cancer-specific mortality in penile cancer patients treated with definitive surgery |
title_sort | external validation of nomograms for predicting cancer-specific mortality in penile cancer patients treated with definitive surgery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026545/ https://www.ncbi.nlm.nih.gov/pubmed/24559854 http://dx.doi.org/10.5732/cjc.013.10176 |
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