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Characterization of rice bran wax policosanol and its nanoemulsion formulation
Policosanol, a mixture of long-chain alcohols found in animal and plant waxes, has several biological effects; however, it has a bioavailability of less than 10%. Therefore, there is a need to improve its bioavailability, and one of the ways of doing this is by nanoemulsion formulation. Different dr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026553/ https://www.ncbi.nlm.nih.gov/pubmed/24872689 http://dx.doi.org/10.2147/IJN.S56999 |
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author | Ishaka, Aminu Umar Imam, Mustapha Mahamud, Rozi Zuki, Abu Bakar Zakaria Maznah, Ismail |
author_facet | Ishaka, Aminu Umar Imam, Mustapha Mahamud, Rozi Zuki, Abu Bakar Zakaria Maznah, Ismail |
author_sort | Ishaka, Aminu |
collection | PubMed |
description | Policosanol, a mixture of long-chain alcohols found in animal and plant waxes, has several biological effects; however, it has a bioavailability of less than 10%. Therefore, there is a need to improve its bioavailability, and one of the ways of doing this is by nanoemulsion formulation. Different droplet size distributions are usually achieved when emulsions are formed, which solely depends on the preparation method used. Mostly, emulsions are intended for better delivery with maintenance of the characteristics and properties of the leading components. In this study, policosanol was extracted from rice bran wax, its composition was determined by gas chromatography mass spectrophotometry, nanoemulsion was made, and the physical stability characteristics were determined. The results showed that policosanol nanoemulsion has a nanosize particle distribution below 100 nm (92.56–94.52 nm), with optimum charge distribution (−55.8 to −45.12 mV), pH (6.79–6.92) and refractive index (1.50); these were monitored and found to be stable for 8 weeks. The stability of policosanol nanoemulsion confers the potential to withstand long storage times. |
format | Online Article Text |
id | pubmed-4026553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40265532014-05-28 Characterization of rice bran wax policosanol and its nanoemulsion formulation Ishaka, Aminu Umar Imam, Mustapha Mahamud, Rozi Zuki, Abu Bakar Zakaria Maznah, Ismail Int J Nanomedicine Original Research Policosanol, a mixture of long-chain alcohols found in animal and plant waxes, has several biological effects; however, it has a bioavailability of less than 10%. Therefore, there is a need to improve its bioavailability, and one of the ways of doing this is by nanoemulsion formulation. Different droplet size distributions are usually achieved when emulsions are formed, which solely depends on the preparation method used. Mostly, emulsions are intended for better delivery with maintenance of the characteristics and properties of the leading components. In this study, policosanol was extracted from rice bran wax, its composition was determined by gas chromatography mass spectrophotometry, nanoemulsion was made, and the physical stability characteristics were determined. The results showed that policosanol nanoemulsion has a nanosize particle distribution below 100 nm (92.56–94.52 nm), with optimum charge distribution (−55.8 to −45.12 mV), pH (6.79–6.92) and refractive index (1.50); these were monitored and found to be stable for 8 weeks. The stability of policosanol nanoemulsion confers the potential to withstand long storage times. Dove Medical Press 2014-05-09 /pmc/articles/PMC4026553/ /pubmed/24872689 http://dx.doi.org/10.2147/IJN.S56999 Text en © 2014 Ishaka et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ishaka, Aminu Umar Imam, Mustapha Mahamud, Rozi Zuki, Abu Bakar Zakaria Maznah, Ismail Characterization of rice bran wax policosanol and its nanoemulsion formulation |
title | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
title_full | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
title_fullStr | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
title_full_unstemmed | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
title_short | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
title_sort | characterization of rice bran wax policosanol and its nanoemulsion formulation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026553/ https://www.ncbi.nlm.nih.gov/pubmed/24872689 http://dx.doi.org/10.2147/IJN.S56999 |
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