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Central Hyperthermia Treated With Baclofen for Patient With Pontine Hemorrhage

Central hyperthermia is a very rare disease; however, once it happens, it is associated with a poor prognosis and high mortality for patients with severe brainstem strokes. Following a pontine hemorrhage, a 46-years-old female developed prolonged hyperthermia. Work-ups to the fever gave no significa...

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Autores principales: Lee, Hyun Cheol, Kim, Jong Moon, Lim, Jae Kuk, Jo, Yoon Sik, Kim, Shin Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Rehabilitation Medicine 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026615/
https://www.ncbi.nlm.nih.gov/pubmed/24855623
http://dx.doi.org/10.5535/arm.2014.38.2.269
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author Lee, Hyun Cheol
Kim, Jong Moon
Lim, Jae Kuk
Jo, Yoon Sik
Kim, Shin Kyoung
author_facet Lee, Hyun Cheol
Kim, Jong Moon
Lim, Jae Kuk
Jo, Yoon Sik
Kim, Shin Kyoung
author_sort Lee, Hyun Cheol
collection PubMed
description Central hyperthermia is a very rare disease; however, once it happens, it is associated with a poor prognosis and high mortality for patients with severe brainstem strokes. Following a pontine hemorrhage, a 46-years-old female developed prolonged hyperthermia. Work-ups to the fever gave no significant clues for the origin of fever, and hyperthermia did not respond to any empirical antibiotics or antipyretic agents. The patient's body temperature still fluctuated in a range of 37.5℃ to 39.2℃. Considering the lesion of hemorrhage, we suspected central hyperthermia rather than infectious diseases. We started with baclofen administration at a dose of 30 mg/day. The body temperature changed to a range of 36.6℃ to 38.2℃. We raised the dose of baclofen to 60 mg/day. The patient's body temperature finally dropped to a normal range. Central hyperthermia, caused by failures of thermoregulatory pathways in brainstem, following the pontine hemorrhage rarely occurs. Baclofen can be used to treat suspected central hyperthermia in a patient with pontine hemorrhage.
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spelling pubmed-40266152014-05-22 Central Hyperthermia Treated With Baclofen for Patient With Pontine Hemorrhage Lee, Hyun Cheol Kim, Jong Moon Lim, Jae Kuk Jo, Yoon Sik Kim, Shin Kyoung Ann Rehabil Med Case Report Central hyperthermia is a very rare disease; however, once it happens, it is associated with a poor prognosis and high mortality for patients with severe brainstem strokes. Following a pontine hemorrhage, a 46-years-old female developed prolonged hyperthermia. Work-ups to the fever gave no significant clues for the origin of fever, and hyperthermia did not respond to any empirical antibiotics or antipyretic agents. The patient's body temperature still fluctuated in a range of 37.5℃ to 39.2℃. Considering the lesion of hemorrhage, we suspected central hyperthermia rather than infectious diseases. We started with baclofen administration at a dose of 30 mg/day. The body temperature changed to a range of 36.6℃ to 38.2℃. We raised the dose of baclofen to 60 mg/day. The patient's body temperature finally dropped to a normal range. Central hyperthermia, caused by failures of thermoregulatory pathways in brainstem, following the pontine hemorrhage rarely occurs. Baclofen can be used to treat suspected central hyperthermia in a patient with pontine hemorrhage. Korean Academy of Rehabilitation Medicine 2014-04 2014-04-29 /pmc/articles/PMC4026615/ /pubmed/24855623 http://dx.doi.org/10.5535/arm.2014.38.2.269 Text en Copyright © 2014 by Korean Academy of Rehabilitation Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Hyun Cheol
Kim, Jong Moon
Lim, Jae Kuk
Jo, Yoon Sik
Kim, Shin Kyoung
Central Hyperthermia Treated With Baclofen for Patient With Pontine Hemorrhage
title Central Hyperthermia Treated With Baclofen for Patient With Pontine Hemorrhage
title_full Central Hyperthermia Treated With Baclofen for Patient With Pontine Hemorrhage
title_fullStr Central Hyperthermia Treated With Baclofen for Patient With Pontine Hemorrhage
title_full_unstemmed Central Hyperthermia Treated With Baclofen for Patient With Pontine Hemorrhage
title_short Central Hyperthermia Treated With Baclofen for Patient With Pontine Hemorrhage
title_sort central hyperthermia treated with baclofen for patient with pontine hemorrhage
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026615/
https://www.ncbi.nlm.nih.gov/pubmed/24855623
http://dx.doi.org/10.5535/arm.2014.38.2.269
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