Systems Pharmacology Models Can Be Used to Understand Complex Pharmacokinetic-Pharmacodynamic Behavior: An Example Using 5-Lipoxygenase Inhibitors

Zileuton, a 5-lipoxygenase (5LO) inhibitor, displays complex pharmaokinetic (PK)-pharmacodynamic (PD) behavior. Available clinical data indicate a lack of dose–bronchodilatory response during initial treatment, with a dose response developing after ~1–2 weeks. We developed a quantitative systems pha...

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Detalles Bibliográficos
Autores principales: Demin, O, Karelina, T, Svetlichniy, D, Metelkin, E, Speshilov, G, Demin Jr, O, Fairman, D, van der Graaf, P H, Agoram, B M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026633/
https://www.ncbi.nlm.nih.gov/pubmed/24026253
http://dx.doi.org/10.1038/psp.2013.49

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