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Mechanistic Vs. Empirical Network Models of Drug Action
Declining success rates coupled with increased costs is leading to an inevitable breaking point in the drug development pipeline. Can we avoid it by incorporating the vast mechanistic understanding of drug action? A recent review highlights this dilemma and proposes “quantitative logic gate” modelin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026635/ https://www.ncbi.nlm.nih.gov/pubmed/24448020 http://dx.doi.org/10.1038/psp.2013.51 |