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Impact of prehypertension on left ventricular mass and QT dispersion in adult black Nigerians
BACKGROUND: Prehypertension has been associated with target-organ damage. This study sought to determine the impact of prehypertension (PHT) on QT dispersion and left ventricular hypertrophy (LVH) in adult black Nigerians. METHODS: One hundred and one subjects with office blood pressure (BP) < 14...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Clinics Cardive Publishing
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026767/ https://www.ncbi.nlm.nih.gov/pubmed/24844553 http://dx.doi.org/10.5830/CVJA-2014-010 |
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author | Ale, OK Ajuluchukwu, JN Oke, DA Mbakwem, AC |
author_facet | Ale, OK Ajuluchukwu, JN Oke, DA Mbakwem, AC |
author_sort | Ale, OK |
collection | PubMed |
description | BACKGROUND: Prehypertension has been associated with target-organ damage. This study sought to determine the impact of prehypertension (PHT) on QT dispersion and left ventricular hypertrophy (LVH) in adult black Nigerians. METHODS: One hundred and one subjects with office blood pressure (BP) < 140/90 mmHg were categorised according to their office BP into normotensive (BP < 120/80 mmHg, n = 57) and prehypertensive (BP 120–139/80–89 mmHg, n = 44) groups. Echocardiography and electrocardiography (ECG) were performed on the subjects. RESULTS: Thirty-four males aged 53.65 ± 16.33 years and 67 females aged 52.42 ± 12.00 years were studied. The mean QT interval dispersion (QTd) of the normotensive (38.96 ± 11.06 ms) and prehypertensive (38.41 ± 11.81 ms) groups were similar (p = 0.81). Prehypertensive subjects had higher left ventricular mass (LVM) (165.75 ± 33.21 vs 144.54 ± 35.55 g, p = 0.024), left ventricular mass index 1 (LVMI-1) (91.65 ± 16.84 vs 80.45 ± 18.65 g/m(2), p = 0.021) and left ventricular mass index 2 (LVMI-2) (54.96 ± 10.84 vs 47.51 ± 12.00 g/m(2.7), p = 0.017). QTd was independent of echocardiographic and electrocardiographic LVH (p > 0.05). CONCLUSION: Compared with normotension, prehypertension is associated with higher LVM but similar QTd. This suggests that structural remodelling precedes electrical remodelling in prehypertension. |
format | Online Article Text |
id | pubmed-4026767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Clinics Cardive Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-40267672014-05-30 Impact of prehypertension on left ventricular mass and QT dispersion in adult black Nigerians Ale, OK Ajuluchukwu, JN Oke, DA Mbakwem, AC Cardiovasc J Afr Cardiovascular Topics BACKGROUND: Prehypertension has been associated with target-organ damage. This study sought to determine the impact of prehypertension (PHT) on QT dispersion and left ventricular hypertrophy (LVH) in adult black Nigerians. METHODS: One hundred and one subjects with office blood pressure (BP) < 140/90 mmHg were categorised according to their office BP into normotensive (BP < 120/80 mmHg, n = 57) and prehypertensive (BP 120–139/80–89 mmHg, n = 44) groups. Echocardiography and electrocardiography (ECG) were performed on the subjects. RESULTS: Thirty-four males aged 53.65 ± 16.33 years and 67 females aged 52.42 ± 12.00 years were studied. The mean QT interval dispersion (QTd) of the normotensive (38.96 ± 11.06 ms) and prehypertensive (38.41 ± 11.81 ms) groups were similar (p = 0.81). Prehypertensive subjects had higher left ventricular mass (LVM) (165.75 ± 33.21 vs 144.54 ± 35.55 g, p = 0.024), left ventricular mass index 1 (LVMI-1) (91.65 ± 16.84 vs 80.45 ± 18.65 g/m(2), p = 0.021) and left ventricular mass index 2 (LVMI-2) (54.96 ± 10.84 vs 47.51 ± 12.00 g/m(2.7), p = 0.017). QTd was independent of echocardiographic and electrocardiographic LVH (p > 0.05). CONCLUSION: Compared with normotension, prehypertension is associated with higher LVM but similar QTd. This suggests that structural remodelling precedes electrical remodelling in prehypertension. Clinics Cardive Publishing 2014-04 /pmc/articles/PMC4026767/ /pubmed/24844553 http://dx.doi.org/10.5830/CVJA-2014-010 Text en Copyright © 2010 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cardiovascular Topics Ale, OK Ajuluchukwu, JN Oke, DA Mbakwem, AC Impact of prehypertension on left ventricular mass and QT dispersion in adult black Nigerians |
title | Impact of prehypertension on left ventricular mass and QT dispersion in adult black Nigerians |
title_full | Impact of prehypertension on left ventricular mass and QT dispersion in adult black Nigerians |
title_fullStr | Impact of prehypertension on left ventricular mass and QT dispersion in adult black Nigerians |
title_full_unstemmed | Impact of prehypertension on left ventricular mass and QT dispersion in adult black Nigerians |
title_short | Impact of prehypertension on left ventricular mass and QT dispersion in adult black Nigerians |
title_sort | impact of prehypertension on left ventricular mass and qt dispersion in adult black nigerians |
topic | Cardiovascular Topics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026767/ https://www.ncbi.nlm.nih.gov/pubmed/24844553 http://dx.doi.org/10.5830/CVJA-2014-010 |
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