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Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence

BACKGROUND: Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients' care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed t...

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Autores principales: Lee, Eunjung, Jung, Wonkyung, Woo, Jeong-Soo, Lee, Jae Bok, Shin, Bong Kyung, Kim, Han Kyeom, Kim, Aeree, Kim, Baek-hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and The Korean Society for Cytopathology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026802/
https://www.ncbi.nlm.nih.gov/pubmed/24868224
http://dx.doi.org/10.4132/KoreanJPathol.2014.48.2.117
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author Lee, Eunjung
Jung, Wonkyung
Woo, Jeong-Soo
Lee, Jae Bok
Shin, Bong Kyung
Kim, Han Kyeom
Kim, Aeree
Kim, Baek-hui
author_facet Lee, Eunjung
Jung, Wonkyung
Woo, Jeong-Soo
Lee, Jae Bok
Shin, Bong Kyung
Kim, Han Kyeom
Kim, Aeree
Kim, Baek-hui
author_sort Lee, Eunjung
collection PubMed
description BACKGROUND: Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients' care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, 'tumor sprouting,' and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence. METHODS: We analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics. RESULTS: Tumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence-free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence. CONCLUSIONS: In conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis.
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spelling pubmed-40268022014-05-27 Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence Lee, Eunjung Jung, Wonkyung Woo, Jeong-Soo Lee, Jae Bok Shin, Bong Kyung Kim, Han Kyeom Kim, Aeree Kim, Baek-hui Korean J Pathol Original Article BACKGROUND: Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients' care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, 'tumor sprouting,' and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence. METHODS: We analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics. RESULTS: Tumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence-free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence. CONCLUSIONS: In conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis. The Korean Society of Pathologists and The Korean Society for Cytopathology 2014-04 2014-04-28 /pmc/articles/PMC4026802/ /pubmed/24868224 http://dx.doi.org/10.4132/KoreanJPathol.2014.48.2.117 Text en © 2014 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Eunjung
Jung, Wonkyung
Woo, Jeong-Soo
Lee, Jae Bok
Shin, Bong Kyung
Kim, Han Kyeom
Kim, Aeree
Kim, Baek-hui
Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
title Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
title_full Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
title_fullStr Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
title_full_unstemmed Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
title_short Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
title_sort tumor sprouting in papillary thyroid carcinoma is correlated with lymph node metastasis and recurrence
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026802/
https://www.ncbi.nlm.nih.gov/pubmed/24868224
http://dx.doi.org/10.4132/KoreanJPathol.2014.48.2.117
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