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The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship
Hyperuricemia is a common finding in chronic kidney disease due to decreased uric acid clearance. The role of uric acid as a risk factor for chronic kidney disease has been largely debated, and recent studies suggested a role of uric acid in the causation and progression of kidney fibrosis, a final...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026934/ https://www.ncbi.nlm.nih.gov/pubmed/24877124 http://dx.doi.org/10.1155/2014/638732 |
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author | Kim, Il Young Lee, Dong Won Lee, Soo Bong Kwak, Ihm Soo |
author_facet | Kim, Il Young Lee, Dong Won Lee, Soo Bong Kwak, Ihm Soo |
author_sort | Kim, Il Young |
collection | PubMed |
description | Hyperuricemia is a common finding in chronic kidney disease due to decreased uric acid clearance. The role of uric acid as a risk factor for chronic kidney disease has been largely debated, and recent studies suggested a role of uric acid in the causation and progression of kidney fibrosis, a final common pathway in chronic kidney disease. Uric acid and xanthine oxidase may contribute to kidney fibrosis mainly by inducing inflammation, endothelial dysfunction, oxidative stress, and activation of the renin-angiotensin system. Besides, hyperuricemia induces alterations in renal hemodynamics via afferent arteriolopathy and contributes to the onset and progression of kidney fibrosis. Xanthine oxidase inhibitors may prevent kidney damage via lowering uric acid and/or inhibiting xanthine oxidase. However, there is still no sufficient evidence from interventional clinical researches supporting the causal relationship between uric acid and kidney fibrosis. The effect and role of xanthine oxidase inhibitors in preventing kidney fibrosis and chronic kidney disease progression must be further explored by performing future large scale clinical trials. |
format | Online Article Text |
id | pubmed-4026934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40269342014-05-29 The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship Kim, Il Young Lee, Dong Won Lee, Soo Bong Kwak, Ihm Soo Biomed Res Int Review Article Hyperuricemia is a common finding in chronic kidney disease due to decreased uric acid clearance. The role of uric acid as a risk factor for chronic kidney disease has been largely debated, and recent studies suggested a role of uric acid in the causation and progression of kidney fibrosis, a final common pathway in chronic kidney disease. Uric acid and xanthine oxidase may contribute to kidney fibrosis mainly by inducing inflammation, endothelial dysfunction, oxidative stress, and activation of the renin-angiotensin system. Besides, hyperuricemia induces alterations in renal hemodynamics via afferent arteriolopathy and contributes to the onset and progression of kidney fibrosis. Xanthine oxidase inhibitors may prevent kidney damage via lowering uric acid and/or inhibiting xanthine oxidase. However, there is still no sufficient evidence from interventional clinical researches supporting the causal relationship between uric acid and kidney fibrosis. The effect and role of xanthine oxidase inhibitors in preventing kidney fibrosis and chronic kidney disease progression must be further explored by performing future large scale clinical trials. Hindawi Publishing Corporation 2014 2014-05-05 /pmc/articles/PMC4026934/ /pubmed/24877124 http://dx.doi.org/10.1155/2014/638732 Text en Copyright © 2014 Il Young Kim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kim, Il Young Lee, Dong Won Lee, Soo Bong Kwak, Ihm Soo The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship |
title | The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship |
title_full | The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship |
title_fullStr | The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship |
title_full_unstemmed | The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship |
title_short | The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship |
title_sort | role of uric acid in kidney fibrosis: experimental evidences for the causal relationship |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026934/ https://www.ncbi.nlm.nih.gov/pubmed/24877124 http://dx.doi.org/10.1155/2014/638732 |
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