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Aluminium hydroxide stabilised MnFe(2)O(4) and Fe(3)O(4) nanoparticles as dual-modality contrasts agent for MRI and PET imaging

Magnetic nanoparticles (NPs) MnFe(2)O(4) and Fe(3)O(4) were stabilised by depositing an Al(OH)(3) layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for...

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Autores principales: Cui, Xianjin, Belo, Salome, Krüger, Dirk, Yan, Yong, de Rosales, Rafael T.M., Jauregui-Osoro, Maite, Ye, Haitao, Su, Shi, Mathe, Domokos, Kovács, Noémi, Horváth, Ildikó, Semjeni, Mariann, Sunassee, Kavitha, Szigeti, Krisztian, Green, Mark A., Blower, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026944/
https://www.ncbi.nlm.nih.gov/pubmed/24768194
http://dx.doi.org/10.1016/j.biomaterials.2014.04.004
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author Cui, Xianjin
Belo, Salome
Krüger, Dirk
Yan, Yong
de Rosales, Rafael T.M.
Jauregui-Osoro, Maite
Ye, Haitao
Su, Shi
Mathe, Domokos
Kovács, Noémi
Horváth, Ildikó
Semjeni, Mariann
Sunassee, Kavitha
Szigeti, Krisztian
Green, Mark A.
Blower, Philip J.
author_facet Cui, Xianjin
Belo, Salome
Krüger, Dirk
Yan, Yong
de Rosales, Rafael T.M.
Jauregui-Osoro, Maite
Ye, Haitao
Su, Shi
Mathe, Domokos
Kovács, Noémi
Horváth, Ildikó
Semjeni, Mariann
Sunassee, Kavitha
Szigeti, Krisztian
Green, Mark A.
Blower, Philip J.
author_sort Cui, Xianjin
collection PubMed
description Magnetic nanoparticles (NPs) MnFe(2)O(4) and Fe(3)O(4) were stabilised by depositing an Al(OH)(3) layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)(3) layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)(3) coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu.
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spelling pubmed-40269442014-07-01 Aluminium hydroxide stabilised MnFe(2)O(4) and Fe(3)O(4) nanoparticles as dual-modality contrasts agent for MRI and PET imaging Cui, Xianjin Belo, Salome Krüger, Dirk Yan, Yong de Rosales, Rafael T.M. Jauregui-Osoro, Maite Ye, Haitao Su, Shi Mathe, Domokos Kovács, Noémi Horváth, Ildikó Semjeni, Mariann Sunassee, Kavitha Szigeti, Krisztian Green, Mark A. Blower, Philip J. Biomaterials Article Magnetic nanoparticles (NPs) MnFe(2)O(4) and Fe(3)O(4) were stabilised by depositing an Al(OH)(3) layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)(3) layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)(3) coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu. Elsevier Science 2014-07 /pmc/articles/PMC4026944/ /pubmed/24768194 http://dx.doi.org/10.1016/j.biomaterials.2014.04.004 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Cui, Xianjin
Belo, Salome
Krüger, Dirk
Yan, Yong
de Rosales, Rafael T.M.
Jauregui-Osoro, Maite
Ye, Haitao
Su, Shi
Mathe, Domokos
Kovács, Noémi
Horváth, Ildikó
Semjeni, Mariann
Sunassee, Kavitha
Szigeti, Krisztian
Green, Mark A.
Blower, Philip J.
Aluminium hydroxide stabilised MnFe(2)O(4) and Fe(3)O(4) nanoparticles as dual-modality contrasts agent for MRI and PET imaging
title Aluminium hydroxide stabilised MnFe(2)O(4) and Fe(3)O(4) nanoparticles as dual-modality contrasts agent for MRI and PET imaging
title_full Aluminium hydroxide stabilised MnFe(2)O(4) and Fe(3)O(4) nanoparticles as dual-modality contrasts agent for MRI and PET imaging
title_fullStr Aluminium hydroxide stabilised MnFe(2)O(4) and Fe(3)O(4) nanoparticles as dual-modality contrasts agent for MRI and PET imaging
title_full_unstemmed Aluminium hydroxide stabilised MnFe(2)O(4) and Fe(3)O(4) nanoparticles as dual-modality contrasts agent for MRI and PET imaging
title_short Aluminium hydroxide stabilised MnFe(2)O(4) and Fe(3)O(4) nanoparticles as dual-modality contrasts agent for MRI and PET imaging
title_sort aluminium hydroxide stabilised mnfe(2)o(4) and fe(3)o(4) nanoparticles as dual-modality contrasts agent for mri and pet imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026944/
https://www.ncbi.nlm.nih.gov/pubmed/24768194
http://dx.doi.org/10.1016/j.biomaterials.2014.04.004
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