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Assessing Function and Endurance in Adults with Spinal and Bulbar Muscular Atrophy: Validity of the Adult Myopathy Assessment Tool

Purpose. The adult myopathy assessment tool (AMAT) is a performance-based battery comprised of functional and endurance subscales that can be completed in approximately 30 minutes without the use of specialized equipment. The purpose of this study was to determine the construct validity and internal...

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Autores principales: Harris-Love, Michael O., Fernandez-Rhodes, Lindsay, Joe, Galen, Shrader, Joseph A., Kokkinis, Angela, La Pean Kirschner, Alison, Auh, Sungyoung, Chen, Cheunju, Li, Li, Levy, Ellen, Davenport, Todd E., Di Prospero, Nicholas A., Fischbeck, Kenneth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026974/
https://www.ncbi.nlm.nih.gov/pubmed/24876969
http://dx.doi.org/10.1155/2014/873872
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author Harris-Love, Michael O.
Fernandez-Rhodes, Lindsay
Joe, Galen
Shrader, Joseph A.
Kokkinis, Angela
La Pean Kirschner, Alison
Auh, Sungyoung
Chen, Cheunju
Li, Li
Levy, Ellen
Davenport, Todd E.
Di Prospero, Nicholas A.
Fischbeck, Kenneth H.
author_facet Harris-Love, Michael O.
Fernandez-Rhodes, Lindsay
Joe, Galen
Shrader, Joseph A.
Kokkinis, Angela
La Pean Kirschner, Alison
Auh, Sungyoung
Chen, Cheunju
Li, Li
Levy, Ellen
Davenport, Todd E.
Di Prospero, Nicholas A.
Fischbeck, Kenneth H.
author_sort Harris-Love, Michael O.
collection PubMed
description Purpose. The adult myopathy assessment tool (AMAT) is a performance-based battery comprised of functional and endurance subscales that can be completed in approximately 30 minutes without the use of specialized equipment. The purpose of this study was to determine the construct validity and internal consistency of the AMAT with a sample of adults with spinal and bulbar muscular atrophy (SBMA). Methods. AMAT validity was assessed in 56-male participants with genetically confirmed SBMA (mean age, 53 ± 10 years). The participants completed the AMAT and assessments for disease status, strength, and functional status. Results. Lower AMAT scores were associated with longer disease duration (r = −0.29; P < 0.03) and lower serum androgen levels (r = 0.49–0.59; P < 0.001). The AMAT was significantly correlated with strength and functional status (r = 0.82–0.88; P < 0.001). The domains of the AMAT exhibited good internal consistency (Cronbach's α = 0.77–0.89; P < 0.001). Conclusions. The AMAT is a standardized, performance-based tool that may be used to assess functional limitations and muscle endurance. The AMAT has good internal consistency, and the construct validity of the AMAT is supported by its significant associations with hormonal, strength, and functional characteristics of adults with SBMA. This trial is registered with Clinicaltrials.gov identifier NCT00303446.
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spelling pubmed-40269742014-05-29 Assessing Function and Endurance in Adults with Spinal and Bulbar Muscular Atrophy: Validity of the Adult Myopathy Assessment Tool Harris-Love, Michael O. Fernandez-Rhodes, Lindsay Joe, Galen Shrader, Joseph A. Kokkinis, Angela La Pean Kirschner, Alison Auh, Sungyoung Chen, Cheunju Li, Li Levy, Ellen Davenport, Todd E. Di Prospero, Nicholas A. Fischbeck, Kenneth H. Rehabil Res Pract Research Article Purpose. The adult myopathy assessment tool (AMAT) is a performance-based battery comprised of functional and endurance subscales that can be completed in approximately 30 minutes without the use of specialized equipment. The purpose of this study was to determine the construct validity and internal consistency of the AMAT with a sample of adults with spinal and bulbar muscular atrophy (SBMA). Methods. AMAT validity was assessed in 56-male participants with genetically confirmed SBMA (mean age, 53 ± 10 years). The participants completed the AMAT and assessments for disease status, strength, and functional status. Results. Lower AMAT scores were associated with longer disease duration (r = −0.29; P < 0.03) and lower serum androgen levels (r = 0.49–0.59; P < 0.001). The AMAT was significantly correlated with strength and functional status (r = 0.82–0.88; P < 0.001). The domains of the AMAT exhibited good internal consistency (Cronbach's α = 0.77–0.89; P < 0.001). Conclusions. The AMAT is a standardized, performance-based tool that may be used to assess functional limitations and muscle endurance. The AMAT has good internal consistency, and the construct validity of the AMAT is supported by its significant associations with hormonal, strength, and functional characteristics of adults with SBMA. This trial is registered with Clinicaltrials.gov identifier NCT00303446. Hindawi Publishing Corporation 2014 2014-05-05 /pmc/articles/PMC4026974/ /pubmed/24876969 http://dx.doi.org/10.1155/2014/873872 Text en Copyright © 2014 Michael O. Harris-Love et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Harris-Love, Michael O.
Fernandez-Rhodes, Lindsay
Joe, Galen
Shrader, Joseph A.
Kokkinis, Angela
La Pean Kirschner, Alison
Auh, Sungyoung
Chen, Cheunju
Li, Li
Levy, Ellen
Davenport, Todd E.
Di Prospero, Nicholas A.
Fischbeck, Kenneth H.
Assessing Function and Endurance in Adults with Spinal and Bulbar Muscular Atrophy: Validity of the Adult Myopathy Assessment Tool
title Assessing Function and Endurance in Adults with Spinal and Bulbar Muscular Atrophy: Validity of the Adult Myopathy Assessment Tool
title_full Assessing Function and Endurance in Adults with Spinal and Bulbar Muscular Atrophy: Validity of the Adult Myopathy Assessment Tool
title_fullStr Assessing Function and Endurance in Adults with Spinal and Bulbar Muscular Atrophy: Validity of the Adult Myopathy Assessment Tool
title_full_unstemmed Assessing Function and Endurance in Adults with Spinal and Bulbar Muscular Atrophy: Validity of the Adult Myopathy Assessment Tool
title_short Assessing Function and Endurance in Adults with Spinal and Bulbar Muscular Atrophy: Validity of the Adult Myopathy Assessment Tool
title_sort assessing function and endurance in adults with spinal and bulbar muscular atrophy: validity of the adult myopathy assessment tool
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026974/
https://www.ncbi.nlm.nih.gov/pubmed/24876969
http://dx.doi.org/10.1155/2014/873872
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