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TNFα-mediated Hsd11b1 binding of NF-κB p65 is associated with suppression of 11β-HSD1 in muscle

The activity of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive cortisone (11-dehydrocorticosterone (11-DHC)) (in mice) into the active glucocorticoid (GC) cortisol (corticosterone in mice), can amplify tissue GC exposure. Elevated TNFα is a common feature in a...

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Detalles Bibliográficos
Autores principales:	Doig, Craig L, Bashir, Jamila, Zielinska, Agnieszka E, Cooper, Mark S, Stewart, Paul M, Lavery, Gareth G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioScientifica 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027025/ https://www.ncbi.nlm.nih.gov/pubmed/24413279 http://dx.doi.org/10.1530/JOE-13-0494

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