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Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides

Antisense oligonucleotides (ASOs) are synthetic oligonucleotides that alter expression of disease-associated transcripts via Watson–Crick hybridization. ASOs that function through RNase H or the RNA-induced silencing complex (RISC) result in enzymatic degradation of target RNA. ASOs designed to ster...

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Detalles Bibliográficos
Autores principales:	Ward, Amanda J., Norrbom, Michaela, Chun, Seung, Bennett, C. Frank, Rigo, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027159/ https://www.ncbi.nlm.nih.gov/pubmed/24589581 http://dx.doi.org/10.1093/nar/gku184

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