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A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression

Accumulating evidence suggests that dormant DNA replication origins play an important role in the recovery of stalled forks. However, their functional interactions with other fork recovery mechanisms have not been tested. We previously reported intrinsic activation of the Fanconi anemia (FA) pathway...

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Detalles Bibliográficos
Autores principales:	Luebben, Spencer W., Kawabata, Tsuyoshi, Johnson, Charles S., O'Sullivan, M. Gerard, Shima, Naoko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027174/ https://www.ncbi.nlm.nih.gov/pubmed/24589582 http://dx.doi.org/10.1093/nar/gku170

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