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Exonic splicing signals impose constraints upon the evolution of enzymatic activity

Exon splicing enhancers (ESEs) overlap with amino acid coding sequences implying a dual evolutionary selective pressure. In this study, we map ESEs in the placental alkaline phosphatase gene (ALPP), absent in the corresponding exon of the ancestral tissue-non-specific alkaline phosphatase gene (ALPL...

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Detalles Bibliográficos
Autores principales:	Falanga, Alessia, Stojanović, Ozren, Kiffer-Moreira, Tina, Pinto, Sofia, Millán, José Luis, Vlahoviček, Kristian, Baralle, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027185/ https://www.ncbi.nlm.nih.gov/pubmed/24692663 http://dx.doi.org/10.1093/nar/gku240

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