Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues

The trigger loop (TL) of RNA polymerase II (Pol II) is a conserved structural motif that is crucial for Pol II catalytic activity and transcriptional fidelity. The TL remains in an inactive open conformation when the mismatched substrate is bound. In contrast, TL switches from an inactive open state...

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Detalles Bibliográficos
Autores principales: Xu, Liang, Butler, Kyle Vincent, Chong, Jenny, Wengel, Jesper, Kool, Eric T., Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027217/
https://www.ncbi.nlm.nih.gov/pubmed/24692664
http://dx.doi.org/10.1093/nar/gku238

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