Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.

[Image: see text] The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1–3 showed weak to moderate in vitro antiplasmodial activity against the ch...

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Detalles Bibliográficos
Autores principales: Rasamison, Vincent E., Rakotondraibe, L. Harinantenaina, Slebodnick, Carla, Brodie, Peggy J., Ratsimbason, Michel, TenDyke, Karen, Shen, Yongchun, Randrianjanaka, Lucien M., Kingston, David G. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027945/
https://www.ncbi.nlm.nih.gov/pubmed/24773558
http://dx.doi.org/10.1021/ol500775r
Descripción
Sumario:[Image: see text] The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1–3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the nonsmall lung cancer cell line H522-T1 with an IC(50) value of 16.4 μM.

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