Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma

[Image: see text] BTK is a member of the TEC family of non-receptor tyrosine kinases whose deregulation has been implicated in a variety of B-cell-related diseases. We have used structure-based drug design in conjunction with kinome profiling and cellular assays to develop a potent, selective, and i...

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Detalles Bibliográficos
Autores principales: Wu, Hong, Wang, Wenchao, Liu, Feiyang, Weisberg, Ellen L., Tian, Bei, Chen, Yongfei, Li, Binhua, Wang, Aoli, Wang, Beilei, Zhao, Zheng, McMillin, Douglas W., Hu, Chen, Li, Hong, Wang, Jinhua, Liang, Yanke, Buhrlage, Sara J., Liang, Junting, Liu, Jing, Yang, Guang, Brown, Jennifer R., Treon, Steven P., Mitsiades, Constantine S., Griffin, James D., Liu, Qingsong, Gray, Nathanael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027949/
https://www.ncbi.nlm.nih.gov/pubmed/24556163
http://dx.doi.org/10.1021/cb4008524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027949/
https://www.ncbi.nlm.nih.gov/pubmed/24556163
http://dx.doi.org/10.1021/cb4008524

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