Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease

BACKGROUND: The role of mitochondrial dysfunction has long been implicated in age-related brain pathology, including Alzheimer’s disease (AD). However, the mechanism by which mitochondrial dysfunction may cause neurodegeneration in AD is unclear. To model mitochondrial dysfunction in vivo, we utiliz...

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Detalles Bibliográficos
Autores principales: Kukreja, Lokesh, Kujoth, Gregory C, Prolla, Tomas A, Van Leuven, Fred, Vassar, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028006/
https://www.ncbi.nlm.nih.gov/pubmed/24885175
http://dx.doi.org/10.1186/1750-1326-9-16

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